1. Joseph L. Goldstein - Biography joseph L. goldstein was born on April 18, 1940, in goldstein has served on studysections for the American In addition to the 1985 nobel Prize for Physiology http://www.nobel.se/medicine/laureates/1985/goldstein-bio.html

Joseph L. Goldstein was born on April 18, 1940, in Sumter, South Carolina, the only son of Isadore E. and Fannie Alpert Goldstein. The family owned and operated a clothing store in Kingstree, South Carolina, a town of 5000 people. After his education in the primary and secondary public schools of Kingstree, Goldstein attended Washington and Lee University in Lexington, Virginia, and received the B.S. degree in chemistry, summa cum laude , in 1962. He then attended Southwestern Medical School of the University of Texas Health Science Center in Dallas where he was inspired to pursue a career in academic medicine by Donald W. Seldin, then and now Chairman of the Department of Internal Medicine. During his last year in medical school, Seldin offered Goldstein a future faculty position if he would become trained in genetics and return to Dallas to establish a division of medical genetics in the Department of Internal Medicine. After receiving the M.D. degree in 1966, Goldstein moved to Boston where he was an Intern and Resident in Medicine at the Massachusetts General Hospital (1966-68).It was at the Massachusetts General Hospital that Goldstein first met and developed a friendship with

2. Medicine 1985 The nobel Prize in Physiology or Medicine 1985. for their discoveries concerningthe regulation of cholesterol metabolism . Michael S. Brown, joseph L. goldstein. http://www.nobel.se/medicine/laureates/1985/

The Nobel Prize in Physiology or Medicine 1985 "for their discoveries concerning the regulation of cholesterol metabolism" Michael S. Brown Joseph L. Goldstein 1/2 of the prize 1/2 of the prize USA USA University of Texas Health Science Center at Dallas Dallas, TX, USA University of Texas Health Science Center at Dallas Dallas, TX, USA b. 1941 b. 1940 The Nobel Prize in Physiology or Medicine 1985 Press Release Presentation Speech Michael S. Brown ... Banquet Speech The 1985 Prize in: Physics Chemistry Physiology or Medicine Literature ... Economic Sciences Find a Laureate: Last modified June 16, 2000 The Official Web Site of The Nobel Foundation

3. Joseph L. Goldstein Winner Of The 1985 Nobel Prize In Medicine joseph L. goldstein, a nobel Prize Laureate in Physiology and Medicine,at the nobel Prize Internet Archive. joseph L. goldstein. http://almaz.com/nobel/medicine/1985b.html

J OSEPH L G OLDSTEIN 1985 Nobel Laureate in Medicine for their discoveries concerning the regulation of cholesterol metabolism. Background Born: 1940 Residence: U.S.A. Affiliation: University of Texas Health Science Center at Dallas, Dallas, TX Featured Internet Links Prize co-recipient: Michael S. Brown Search WWW Search The Nobel Prize Internet Archive Nobel News Links Scientist Finds Clue to Higher Level of Cholesterol in Some as They Age 2 Texas Doctors Celebrate Nobel Medicine Prize at MIT Links added by Nobel Internet Archive visitors UT Southwestern - Impact of Nobel Prizes Winner of The Gairdner Foundation Int'l Award Back to The Nobel Prize Internet Archive Literature ... Medicine We always welcome your feedback and comments

4. Index Of Nobel Laureates In Medicine ALPHABETICAL LISTING OF nobel PRIZE LAUREATES IN PHYSIOLOGY AND MEDICINE. Name, YearAwarded. Gilman, Alfred G. 1994. goldstein, joseph L. 1985. Golgi, Camillo, 1906. http://almaz.com/nobel/medicine/alpha.html

ALPHABETICAL LISTING OF NOBEL PRIZE LAUREATES IN PHYSIOLOGY AND MEDICINE Name Year Awarded Adrian, Lord Edgar Douglas Arber, Werner Axelrod, Julius Baltimore, David ... Medicine We always welcome your feedback and comments

5. UT Southwestern Nobel Laureates: Dr. Joseph L. Goldstein Publications. The 1985 nobel Prize in Medicine Michael S. Brown andJoseph L. goldstein (Garfield critique of citation impact). http://www3.utsouthwestern.edu/library/speccol/archives/nobel/goldstein.htm

Joseph L. Goldstein, M.D. Professor of Molecular Genetics and Internal Medicine, Regental Professor, Chairman, Department of Molecular Genetics Dr. Goldstein received the 1985 Nobel Prize in Physiology or Medicine for discoveries concerning the regulation of cholesterol metabolism. "...scientists and academicians now are using the word 'paradigm' to describe the Nobel Prize-winning work of Drs. Michael S. Brown and Joseph L. Goldstein...." Bob Fenley, "Trail of Discovery," Biologue 1986 pgs. 16-18. "The Great Adventure" (from Southwestern Medicine PDF version "Trail of Discovery" (from Southwestern Medicine PDF version Research Interests Nobel Prize Press Release Biography (from the Nobel site) Community of Science Profile and List of Recent Publications "The 1985 Nobel Prize in Medicine - Michael S. Brown and Joseph L. Goldstein..." (Garfield critique of citation impact) Maintained by: Archives Updated: 4/24/2002 Nobel Home Archives Home Special Collections Library Home

6. UT Southwestern Nobel Laureates: Dr. Michael Brown Publications. The 1985 nobel Prize in Medicine Michael S. Brownand joseph L. goldstein (Garfield critique of citation impact). http://www3.utsouthwestern.edu/library/speccol/archives/nobel/brown.htm

Michael Brown, M.D. Professor of Molecular Genetics and Internal Medicine Director, the Erik Jonsson Center for Research in Molecular Genetics and Human Disease Dr. Brown received the 1985 Nobel Prize in Physiology or Medicine for discoveries concerning the regulation of cholesterol metabolism. "'From discovery to understanding the logic of a system one studies...is a very long way; this makes the difference between everyday science and great science — science that outlives for centuries, if not forever, the men and women who dug it out of the darkness of the unknown.' Dr. George E. Palade, Nobel laureate, at a dinner for Goldstein and Brown Pamela Lyon, "The Great Adventure," Biologue 1986 pgs. 10-11, 25. "The Great Adventure" (from Southwestern Medicine PDF version "Trail of Discovery" (from Southwestern Medicine PDF version Research Interests Nobel Prize Press Release Biography (from the Nobel site) Community of Science Profile and List of Recent Publications "The 1985 Nobel Prize in Medicine Michael S. Brown and Joseph L. Goldstein..."

7. Goldstein, Joseph L. joseph L. goldstein, right, with Michael S. Brown, standing in front of a diagramof a cholesterol receptor in full joseph LEONARD goldstein (b. April 18 http://www.britannica.com/nobel/micro/239_22.html

Goldstein, Joseph L., Joseph L. Goldstein, right, with Michael S. Brown, standing in front of a diagram of a cholesterol receptor, 1985 UPI/Corbis-Bettmann in full JOSEPH LEONARD GOLDSTEIN (b. April 18, 1940, Sumter, S.C., U.S.), American molecular geneticist who, along with Michael S. Brown , was awarded the 1985 Nobel Prize for Physiology or Medicine for their elucidation of the process of cholesterol metabolism in the human body. Goldstein received his B.S. degree from Washington and Lee University, Lexington, Va., in 1962 and obtained his medical degree from the Southwestern Medical School of the University of Texas at Dallas in 1966. Goldstein became friends with Brown when they were both working as interns at Massachusetts General Hospital from 1966 to 1968. Goldstein then conducted research under the auspices of the National Institutes of Health from 1968 to 1972, studying genetically predisposing factors that caused the accumulation of blood cholesterol in people prone to heart attacks. He returned to teach at the Southwestern Medical School in Dallas in 1972 and was there reunited with his colleague Brown. The two men then began a concerted study of the processes affecting the accumulation of cholesterol in the bloodstream. In the course of their research they discovered that low-density lipoproteins (LDL), which are primary cholesterol-carrying particles, are withdrawn from the bloodstream into the body's cells by receptors on the cells' surface. The genetic absence of these LDL receptors was found to be the cause of familial hypercholesterolemia, a disorder in which the body's tissues are incapable of removing cholesterol from the bloodstream. The new understanding of the cell receptors' role in the regulation of cholesterol levels in the bloodstream spurred the successful use of drugs and the manipulation of diet in lowering blood cholesterol levels.

8. Nobel Prize Winners GI UK, novelist. goldstein, joseph L. 1985, physiology/medicine, US,discovery of cell receptors relating to cholesterol metabolism, Golgi http://www.britannica.com/nobel/win_g-i.html

9. HHMI News: Joseph L. Goldstein Fue Elegido Miembro Del Directorio Del HHMI Translate this page 5 de septiembre de 2002— joseph L. goldstein, notable científico que compartióel premio nobel de 1985 por descubrimientos relacionados con el metabolismo http://www.hhmi.org/news/090502-esp.html

NOTICIAS DEL INSTITUTO ANUNCIOS DE SUBSIDIOS NOTICIAS DEL INSTITUTO BUSCAR English Version Joseph L. Goldstein fue elegido miembro del directorio del HHMI Joseph L. Goldstein (arriba); Craig B. Thompson Contactar: Avice Meehan, meehana@hhmi.org 4000 Jones Bridge Road, Chevy Chase, MD 20815-6789 Foto: Cortesía de la Centro Médico de Dalas de la Universidad Texas Southwestern (Goldstein); cortesía del Instituto de Investigación del Cáncer de la Familia Abramson (Thompson) Volver arriba 4000 Jones Bridge Road Chevy Chase, MD 20815-6789 E-mail: webmaster@hhmi.org

10. Zeal.com - United States - New - Library - Sciences - Chemistry - Disciplines - 1. Britannica nobel Prizes goldstein, joseph L. http//www.britannica.com/nobel/micro/239_22.htmlRead about this American molecular geneticist who won the http://www.zeal.com/category/preview.jhtml?cid=331421

11. The Lasker Foundation | Awards | This Year's Winners 2002 joseph L. goldstein, Scientific Duopolies. and Kohler and Milstein not to mentionBrown and goldstein. is a recipient of the Lasker Award, the nobel Prize, and http://www.laskerfoundation.org/awards/library/2002_gold_intro.shtml

Lasker Awards Jury Members This Year's Winners Former Winners Ask an Award Winner Do you have a question for this year's award winners... Ask an Award Winner Nominations Open call to... Nominate a Scientist Comments and Acceptance Speeches The 2002 Luncheon Awards Overview of this Year's Awards: Joseph L. Goldstein, Chairman of Lasker Jury Joseph L. Goldstein Scientific Duopolies Far-reaching advances in the medical sciences often result from symbiotic relationships between two scientists. Such pairs or duos achieve success by establishing what I will call a "scientific duopoly." Like twins, there are two types of scientific duopolies - the conjoined type and the separated type. The conjoined duopoly is exemplified by Rodgers and Hammerstein and the separated duopoly by Matisse and Picasso. Let me explain. In a conjoined duopoly, two scientists work together intensely on the same problem in the same laboratory over many years in much the same way that Rodgers and Hammerstein collaborated daily for 19 years to produce the world's most beloved musicals. According to Richard Rodgers, the secret to their success was their ability to think aloud and trade ideas in a constant dialogue, which allowed them to quickly get rid of the many bad ideas so that the rare good ones could be discovered.

12. The Lasker Foundation | About | Lasker Foundation Overview sciences have gone on to receive the nobel Prize, often Watson, Barbara McClintock,Harold Varmus, Stanley Prusiner, joseph L. goldstein, Marshall Nirenberg http://www.laskerfoundation.org/about/ltrust.html

Lasker Foundation Overview Trustees Awards Society Find out how you can participate in our deferred giving program... The Awards Society Lessons Learned The making of a premier Awards Program. Find out how in... Lessons Learned Lasker Awards Learn about the most coveted award in medical science... Lasker Awards Lasker Foundation Overview Albert and Mary Lasker Foundation, Inc. Mission Statement The mission of the Albert and Mary Lasker Foundation is to enlarge public awareness, appreciation, and understanding of promising achievements in medical science in order to increase public support for research. The Foundation rests on the belief that only scientific investigation, and knowledge of basic human biology and disease processes, are the most reliable, efficient means by which to achieve prolongation of life and reduction in human suffering. The centerpiece activity of the Foundation is an annual awards program, which recognizes stunning achievements in basic and clinical research, as well as significant public service in behalf of medical science. The 2002 Winners Pictured above, left to right, Joseph L. Goldstein, Chairman of the Jury; Robin Eady (standing in for Belding H. Scribner), Willem J. Kolff (winners of the 2002 Albert Lasker Award for Clinical Medical Research); James E. Darnell (winner of the 2002 Albert Lasker Award for Special Achievement in Medical Research); James E. Rothman and Randy W. Schekman (winners of the 2002 Albert Lasker Award for Basic Medical Research).

13. News Current News News Releases By Date News Releases By Topic Michael Brown and joseph L. goldstein, UT Southwestern Medical Centerat Dallas, nobel Prize in in Physiology or Medicine, 1985. http://www.utsystem.edu/News/Nobels.htm

News Current News News Releases by Date News Releases by Topic Campus News Offices Media Relations Campus Public Affairs Offices Contact Public Affairs Meetings of the Board of Regents Open Records Information ... Open Records Information About the Campuses Admissions Descriptions Fast Facts Financial Aid/Scholarships ... Tuition and Fees Publications Annual Report Key Statistical Report Fast Facts (Fall 2002) Style Guidelines More Other Resources For Alumni/Friends For Business For Faculty/Staff For Students ... For Visitors U.T. System Home Office of Public Affairs Office of Public Affairs The University of Texas System Colorado Building, Suite 2.150

14. Premios Nobel De Medicina Premios nobel de Medicina. Año, Tema, Ganador. 1985, Brown, Michael S.; goldstein,joseph L. 1986, Cohen, Stanley; LeviMontalcini, Rita. 1987, Tonegawa, Susumu. http://fai.unne.edu.ar/biologia/nobeles/nobelmed.htm

Premios Nobel de Medicina Tema Ganador Behring, Emil Adolf Von Ross, Sir Ronald Finsen, Niels Ryberg Pavlov, Ivan Petrovich Koch, Robert Cajal, Santiago Ramon Y.; Golgi, Camillo Laveran, Charles Louis Alphonse Ehrlich, Paul; Metchnikoff, Ilya Ilyich Kocher, Emil Theodor Kossel, Albrecht Gullstrand, Allvar Carrel, Alexis Richet, Charles Robert Barany, Robert Bordet, Jules Krogh, Schack August Steenberger Hill, Sir Archibald Vivian; Meyerhof, Otto Fritz; Banting, Sir Frederick Grant; Macleod, John James Richard; Einthoven, Willem; Fibiger, Johannes Andreas Grib Wagner-Jauregg, Julius Nicolle, Charles Jules Henri Eijkman, Christiaan; Hopkins, Sir Frederick Gowland Landsteiner, Karl Warburg, Otto Heinrich Adrian, Lord Edgar Douglas; Sherrington, Sir Charles Scott Morgan, Thomas Hunt Minot, George Richards; Murphy, William Parry; Whipple, George Hoyt Spemann, Hans Dale, Sir Henry Hallett; Loewi, Otto Nagyrapolt, Albert Szent-Gyorgyi Von Heymans, Corneille Jean Francois Domagk, Gerhard Dam, Henrik Carl Peter; Doisy, Edward Adelbert Erlanger, Joseph; Gasser, Herbert Spencer

15. The Scientist - Molecular Genetics For years, joseph L. goldstein, chairman and professor of molecular is bound to themembrane, explains goldstein, who shared the 1985 nobel Prize in http://www.the-scientist.com/yr1996/apr/hot2_960415.html

16. The Scientist - Lasker Laureates Make Up Impressive Biomedical No award is better than its recipients, says joseph L. goldstein, winner ofa Lasker in 1985 and a nobel Prize the same year for discovering the basic http://www.the-scientist.com/yr1995/oct/lasker2_951016.html

17. Sponsors And Officers / FAS Jane Owen, Board of Sponsors. *nobel laureate. Sheldon L. Glashow*. Marvin L. Goldberger.joseph L. goldstein*. Roger CL Guillemin*. Herbert A. Hauptman*. http://www.fas.org/sponsor.htm

FAS Homepage Index Search Join FAS FAS Information FAS Board of Directors 1717 K St. NW, Suite 209 Washington, DC 20036 Phone: (202) 546-3300 Fax: (202) 675-1010 E-mail: fas@fas.org Frank von Hippel , Chairman Steve Fetter , Vice-Chairman Henry C. Kelly , President Jonathan Silver , Secretary-Treasurer Bruce Blair Judith Reppy Rosina Bierbaum William Revelle Richard Garwin Shankar Sastry Lawrence Grossman Maxine Savitz Carl Kaysen (ex officio) Gregory Simon Kenneth Luongo Robert Solow (ex officio) Hazel O’Leary Lynn Sykes Tara O'Toole Steven Weinberg Jane Owen Board of Sponsors *Nobel laureate Sidney Altman Bruce Ames Philip W. Anderson Kenneth J. Arrow Julius Axelrod David Baltimore Paul Beeson Baruj Benacerraf Hans A. Bethe J. Michael Bishop Nicolaas Bloembergen ... Paul Boyer Anne Pitts Carter Owen Chamberlain Morris Cohen Stanley Cohen Mildred Cohn Leon N Cooper E.J. Corey Paul B. Cornely James Cronin Johann Deisenhofer Carl Djerassi Ann Druyan Renato Dulbecco John T. Edsall Paul R. Ehrlich George Field Val L. Fitch Jerome D. Frank Jerome I. Friedman John Kenneth Galbraith Walter Gilber Donald Glaser Sheldon L. Glashow

18. Jewish Nobel Prize Laureates - Biomedical Sciences Year, nobel Laureate, Country of birth. 1985, goldstein, joseph L. for theirdiscoveries concerning the regulation of cholesterol metabolism , USA. http://www.science.co.il/Nobel-Biomedical.asp

Israel Science and Technology Homepage HOME Search About Contact Nobel Prize Subject Biomedical Chemistry Economics Physics ... Literature Sort options Country Name Year Order A - Z Z - A Show citation Yes No Jewish Laureates of Nobel Prize in Biomedical Sciences Year Nobel Laureate Country of birth Brenner, Sydney "for their discoveries concerning genetic regulation of organ development and programmed cell death" South Africa Horvitz, H. Robert "for their discoveries concerning genetic regulation of organ development and programmed cell death" USA Greengard, Paul "signal transduction in the nervous system" USA Kandel, Eric R. "signal transduction in the nervous system" Austria Furchgott, Robert F. "for their discoveries concerning nitric oxide as a signaling molecule in the cardiovascular system" USA Prusiner, Stanley B. "for his discovery of Prions - a new biological principle of infection" USA Gilman, Alfred G. "for their discovery of G-proteins and the role of these proteins in signal transduction in cells" USA Rodbell, Martin "for their discovery of G-proteins and the role of these proteins in signal transduction in cells" USA Varmus, Harold E.

19. Regeneron | Company Information | Board Of Directors in cholesterol and lipid metabolism were made in collaboration with Dr. joseph L.goldstein. Dr. Brown, and Dr. goldstein jointly received the nobel Prize for http://www.regeneron.com/company/board.asp

Facilities Senior Management Board of Directors Press Releases Leonard S. Schleifer, M.D., Ph.D., founded our company in 1988 and has been its President and Chief Executive Officer since its inception and served as Chairman of the Board from 1990 through 1994. In 1992, Dr. Schleifer was appointed Clinical Professor of Neurology at the Cornell University Medical School and from 1984 to 1988 he was Assistant Professor at the Cornell University Medical School in the Departments of Neurology and Neurobiology. Dr. Schleifer received his M.D. and Ph.D. in Pharmacology from the University of Virginia. Dr. Schleifer is a licensed physician and is certified in Neurology by the American Board of Psychiatry and Neurology. George D. Yancopoulos, M.D., Ph.D., was until December 2000 our Senior Vice President, Research, a position he held since June 1997 and Chief Scientific Officer, a position he held since January 1998. Dr. Yancopoulos was Vice President, Discovery from January 1992 until June 1997, Head of Discovery from January 1991 to January 1992 and Senior Staff Scientist from March 1989 to January 1991. He received his Ph.D. in Biochemistry and Molecular Biophysics and his M.D. from Columbia University. In a 1997 survey by the Institute for Scientific Information, he was listed among the 11 most highly cited scientists and was the only non-academic scientist in that group. Charles A. Baker has been a director of our company since February 1989. During his career, Mr. Baker served in a senior management capacity in various pharmaceutical companies, including his tenures as Group Vice President, Squibb Corporation (now Bristol-Myers Squibb) and President, Squibb International. He also held various senior executive positions at Abbott Laboratories and Pfizer, Inc. Mr. Baker currently is a member of the Board of Directors of Progenics Pharmaceuticals, Inc. and a member of the Council of Visitors of the Marine Biological Laboratories at Woods Hole, Massachusetts (a not-for-profit organization).

20. ALPHABETICAL LISTING OF NOBEL PRIZE LAUREATES IN PHYSIOLOGY AND MEDICINE FRONTIERS IN BIOSCIENCE; ALPHABETICAL LISTING OF nobel PRIZE LAUREATES INPHYSIOLOGY AND MEDICINE, Name, Year Awarded. goldstein, joseph L. 1985. http://www.bioscience.org/urllists/nobelm.htm

FRONTIERS IN BIOSCIENCE; ALPHABETICAL LISTING OF NOBEL PRIZE LAUREATES IN PHYSIOLOGY AND MEDICINE Name Year Awarded Adrian, Lord Edgar Douglas Arber, Werner Axelrod, Julius Baltimore, David ... Zinkernagel, Rolf M.

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