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Parvovirus B19 is a childhood infectious disease of global proportions. It is the leading cause of erythema infectiousum, affecting mainly young age children. This new book outlines the recent advances in understanding Parvovirus infections in children particularly associated hematological consequences. Also, it describes the associated complications by in utero infection such as hydropes fetalis and acute leukaemia. It has emerged as an occupational viral infection both to health care workers and school workers. It carries the danger of serious infection of recipients of blood and blood products transfusion. ... Read more

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A comprehensive collection of state-of-the-art techniques for generating transgenic plants that are resistant to plant viruses via the cloning and expression of the coat protein gene. Its unfailingly reproducible methods, perfected by hands-on masters, cover the entire process from virus isolation, RNA extraction, and cloning coat protein genes, to the introduction of the coat protein gene into the plant genome and the testing of transgenic plants for resistance. Methods for testing for transformation by PCR and Southern blotting, the detection of RNA transcripts by Northern blotting, and the production of protein by Western analysis are provided, as are methods for challenging the transgenic plants produced and for detecting and measuring the levels of virus.




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The knowledge and practice of clinical virology continues to expand. This new fifth edition has thirty-six comprehensive chapters, each of which has been extensively revised or rewritten, with the addition of new colour plates.

This updated version takes into account knowledge accumulated in molecular biology with its applications for laboratory diagnosis, immunisation and antiviral chemotherapy. Each chapter highlights the clinical features and epidemiological patterns of infection. Similarly, in response to the global concern of the threat posed by new viruses, a new chapter on Emerging Infections is included.  

There is also new material on Hospital Acquired Infections, including some advice relating to SARS, that will be of benefit to those dealing with the day-to-day management of patients in hospital.  ... Read more

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This volume contains 82 chapters that provide detail and understanding to the fields of human and medical virology. The first section describes general features of common human viruses with specialized chapters related to HIV/AIDS. The volume goes on to describe exotic virus infections, including one now eradicated virus (smallpox) and some now controlled by vaccination such as yellow fever. Concepts of medical virology are further developed with entries on viruses associated with oncogenesis and selections of interest to medical virology.

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Because of its high impact on both animal and human health, avian influenza has become a matter of increasing public concern and growing scientific interest within the last decade. This volume gives an overview of the most important results of these research efforts and provides information about the ecology and epidemiology of avian influenza with particular emphasis on recent H5N1 outbreaks in China, Siberia and Europe. Several articles deal with new vaccination strategies, the use of antivirals and other control measures to combat outbreaks of avian influenza.Further chapters illustrate that molecular biology, culminating in the generation of influenza viruses by recombinant DNA technology, was instrumental in unraveling the roles of the viral hemagglutinin and polymerase as well as cellular signaling pathways and innate immunity in pathogenesis and interspecies transmission. Finally, the threat of a pandemic originating from avian influenza viruses is illustrated by the example of the Spanish influenza of 1918.This comprehensive publication on avian influenza viruses and their relevance for human influenza will be of great value to all influenza virologists, molecular biologists, public health scientists, veterinary virologists, ecologists, and scientists engaged in drug design and vaccine development. ... Read more

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Following the considerable success of the first edition of Plant Virology Protocols, this exciting new edition covers the many new techniques that are now applied to the examination and understanding of plant viruses. Each section of Plant Virology Protocols, Second Edition presents the most novel methods and protocols to allow researchers more effective approaches to study plant viruses. The many subjects covered in this important new edition range from techniques for investigating viral nucleic acid sequence, protein analysis and investigation of protein function, techniques for microscopy/GFP visualization and analysis/protein tagging/generation of infectious clones and other such tools, as well as areas of genomics and interactions with host factors and plant-based studies. Plant Virology Protocols, Second Edition: From viral sequence to protein function is indispensable to laboratory investigators studying plant viruses.

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The successful development of a VZV vaccine reflects intense research interest in this virus over recent years. This comprehensive account of the biology and clinical features of the varicella-zoster virus, published in association with the VZV Research Foundation, surveys current knowledge of the molecular biology, pathogenesis, and clinical features of VZV as the causative agent of chickenpox and zoster (shingles). The volume covers such topics as viral replication, latency, immune mechanisms, epidemiology and disease manifestations, and complications of varicella and zoster. Also included is detailed information on live attenuated varicella vaccine, treatment strategies, and the management of postherpetic pain in zoster patients. As the most authoritative review and guide to the virus and its diseases, this book will appeal to a wide range of clinicians and investigators, including pediatricians, geriatricians, neurologists, dermatologists, infectious disease specialists, and virologists interested in the herpes viruses. ... Read more

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Fundamentals of Plant Virology is an introductory student text covering all of modern plant virology. The author, Dr. R.E.F. Matthews, has written this coursebook based on his classic and comprehensive Plant Virology, Third Edition. Four introductory chapters review properties of viruses and cells and techniques used in their study. Five chapters are devoted to current knowledge of all major plant viruses and related pathogens. Seven chapters describe biological properties such as transmission, host response, disease, ecology, control, classification, and evolution of plant viruses. A historical and future overview concludes the text. Fundamentals of Plant Virology is a carefully designed instructional format for a plant virology course. It is also an invaluable resource for students of plant pathology and plant molecular biology.

Key Features
* Summarizes knowledge on all aspects of plant virology
* Condenses all essential material from Plant Virology 3/e
* Compares basic properties of cells and viruses
* Outlines principles of gene manipulation technology
* Discusses serological techniques including monoclonal antibodies
* Geared to student level course ... Read more

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The present book presents a comprehensive review of Human Herpesvirus-6 (HHV-6) infects up to 90% of the world's population and can cause potentially life-threatening diseases. Clinicians typically do not search for HHV-6, and if they do, they will find only few laboratories providing the necessary diagnostic tests that can differentiate between active and latent infection. Adding to this problem is that scientists still disagree about whether serological or molecular assays will be the best diagnostic test, yet there is no disagreement about the inadequacy of many of thecurrently existing assays. Consequently, our knowledge of etiology and pathogenesis of HHV-6 associated diseases can only come from the combined efforts of clinicians, virologists, molecular biologists and pathologists. It is the prime task of this book to summarize the status quo of HHV-6 research and to further stimulate such a collaboration. It will be a valuable reference for both clinical and basic scientists including epidemiologists, virologists, practicing clinicians and infectiologists, pathologists and essentially all scientists entering the field of herpes virus research. ... Read more

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Herpes zoster (shingles) is a serious neurocutaneous disease caused by a reactivation of latent varicella-zoster virus (VZV). It has been underestimated in terms of its burden, particularly in the elderly population and in immunocompromised patients, who can develop severe complications such as postherpetic neuralgia, meningitis or optic nerve damage. This book compiles state-of-the-art reviews on herpes zoster and VZV by leading clinicians and researchers in the field. They cover the molecular biology, latency and reactivation of the virus as well as the diagnosis, clinical manifestations, epidemiology and therapy of VZV infection. Infections in high-risk patients (immunocompromised hosts and bone marrow recipients) and pregnant women are considered in detail. Emphasis is also given to the direction of future research efforts which will be focused on the very early prevention of chronic zoster pain by combined antiviral and analgesic therapy, and on the control of herpes zoster by administering a VZV-specific vaccine.Providing a valuable update on current strategies to diagnose, treat and prevent herpes zoster, this book is of special interest to clinical virologists, dermatologists, neurologists, gerontologists, pediatricians, ophthalmologists, otologists and general physicians. ... Read more

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(Churchill Livingstone) St. Louis Children's Hospital, MO. Provides practical guidance for those using the clinical laboratory to make specific viral diagnoses. Conventional and molecular techniques are integrated to help the clinician make the best use of all available methods. Includes halftone illustrations and charts. DNLM: Virus Diseases--diagnosis. ... Read more

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This is the autobiography of Thomas H. Weller, M. D., a research scientist who helped develop the technique of growing viruses in tissue culture, and who became a world leader in the study of tropical diseases.

The development of tissue culture techniques transformed the field of virology. It led to the identification of many new infectious agents...several of which were discovered by Weller...and led to the development of many viral vaccines, starting with the Salk and Sabin vaccines.

In 1954, Weller shared the Nobel Prize in Medicine or Physiology with Drs. John Enders and Frederick Robbins. ... Read more

Customer Reviews (1)

Stellar
Anthony Komaroff's stellar contibution to this work helps it shine.An enjoyable and informative read. ... Read more

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Institute of Cancer Research, London, U.K.. Methods in Molecular Biology, Volume 8. Compilation of readily repeatable gene transfer and expression methods from workers expert in the use of a variety of recombinant viral vectors. 36 Contributors, primarily U.K.. ... Read more

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Approximately 15 per cent of human cancer incidence can be attributed to virus infection, i.e. viruses represent the second most important risk factor (after tobacco consumption) for cancer development in humans. Today, five virus types are known to be involved in causing human cancer: papillomaviruses, retroviruses, herpesviruses, hepadnaviruses, and flaviviruses. This volume of "Monographs in Virology" provides a comprehensive review of a number of DNA tumor viruses. Leading experts in the field of tumor virology discuss up-to-date information, focusing on the transforming genes of DNA tumor viruses, the mechanisms of transformation and the in vitro methodology used for their identification and characterization. Even though DNA tumor viruses are a diverse group, in vitro studies have revealed several common mechanisms of viral transformation. The individual chapters of the book describe the latest research on the identification of viral oncogenes and their targets. ... Read more