Product Description

After fifteen years and three editions, Introduction to Environmental Toxicology: Molecular Substructures to Ecological Landscapes has become a standard that defines the field of environmental toxicology, and the fourth edition is no exception. The authors take an integrated approach to environmental toxicology that emphasizes scale and context as important factors in understanding effects and management options.

New in the Fourth Edition:

• New author, Dr. Ruth M. Sofield
• 8-page color insert
• A chapter on fate and transport
• Emphasis on the use of all types of models in understanding how nature works
• Revised sections on synergy and atrazine toxicity
• Updated coverage of the analysis of impacts to populations, communities and ecosystems
• Enlarged risk assessment chapter with an in-depth description of a regional scale risk assessment

This edition benefits from the insight of a new author, Dr. Ruth M. Sofield, who prepared the new chapter on the fate and transport of contaminants. The relationship between structure and toxicological properties has been a major theme of this book since its inception and this new chapter expands this fundamental concept to include fate and transport. In the early chapters the use of models in science is discussed and this theme carries throughout the rest of the book.

So much has changed in the fifteen years since the publication of the first edition. The mid-1990s seem so long ago, when our understanding of environmental toxicology was very basic. Ecological risk assessment was in its very early stages and the consideration of the effects of toxicants on landscapes was only beginning. Computation was still hard, genes stayed put, and it was only becoming recognized that xenobiotics could have hormonal effects — developments that are taken for granted in this edition. Written by authors who teach this subject, a feature that is reflected in their straightforward style, the book provides a foundation for understanding environmental toxicology and its application.

Customer Reviews (2)

Environmental Toxicology
Used this book for a toxicology class. Seemed well written, very up to date and not overly technical. A good read.

Outstandingly written and very informative for scientists
Thisis perhaps one of the more intellectual stimulatingtoxicology booksputout for the general public.Landis, unlike many of his modern day contemporaries, literally gives the reader an indepthinsight into the discipline of toxicology as related to biology, chemistry, ecology, and general mathematics. Furthermore,the author significantly explains thebeneficial use of Risk Assessments and Risk Analysis as related to ecotoxicityand exposure in the environment.

From an environmental science standpoint, the authorcommunicates his ideas and theoretical/scientific idealmswell to the reader forhe or she to get a thorough understanding.Terms andscientific expressions as related to the field ofenvironmental toxicology are well explained throughout the text.

Thisbook is a must have for all those desiringa more detailed and thoroughscientific and informative background in thefield ofenvironmental toxicology as it relates to ecotoxicity and environmental fate and exposure of chemicals in the enviroment. ... Read more

Product Description
This new book, written by two outstanding scientists in the field, describes the basic principles of toxic mechanisms and organ toxicity, providing detailed information on specific mechanisms or chemicals for exemplification. The goal is to provide sufficient information that the reader becomes familiar with the basic concepts in toxicology to enable him or her to understand the basic principles in toxicology and to evaluate the risks at given exposures. With this basic understanding the reader also will be able to critically evaluate the available information on a chemical and to identify data gaps.

In addition to the introductory chapters the book will offer the following systematic information, presented in six special sections:

• Principles in Toxicology
• Organ Toxicology
• Methods in Toxicology
• Risk Assessment
• Risk Management
• Toxicity of Chemicals

Fulfilling a demand for such a book, this will be a welcomed introductory text for students and non-experts alike to focus on and understand the principles of hazard identification and risk assessment of toxicants. Relevant to all those studying toxicology, biochemistry, biology, medicine and chemistry, as well as toxicologists in hospitals, universities and in industry. ... Read more

Product Description
Although they are two aspects of the same subject, environmental toxicology and environmental chemistry are usually presented as though they are entirely separate from one another; even their practitioners often seem unaware of the connections. Environmental Toxicology and Chemistry is the first text to tie these subjects closely together, demonstrating the immediate relevance of each subject to the other while also providing basic, easily understandable introductions to both areas. This unique work presents their principles and applications through numerous illustrative examples and special topics that highlight current environmental concerns. It provides up-to-date as well as historical examples of both subjects and includes discussions of ecotoxicology, epidemiology, predictive methods, and other topics not covered in similar texts. It also includes invertebrates and nonmammal vertebrates, plants, and microorganisms, as well as humans and other mammals. Ideal for advanced undergraduate and graduate students in environmental toxicology courses, Environmental Toxicology and Chemistry offers a timely, comprehensive introduction to the principles of toxicology as they apply to our environment. It is also useful for professionals and practitioners in a wide range of environmentally related fields and businesses. ... Read more

Customer Reviews (1)

Simply Outstanding And A Credit To Environmental Toxicology
This textbook is simply an outstanding piece of science. Crosby literally gives the reader a mouthful when dealing with the subjects of environmental toxicology and chemistry.

It is indeed a detailed and indepth textbookwhich covers the basic scientific foundations of environmental toxicologyand chemistry. Additionally, Crosby interwines the two subjects and showshow one is closely related to the other in terms of making adequatescientific risk assessments and writing scientific reviews.

Corsby's workin this particular textbook is nothing short of academically remarkable.This textbook is a must sciendce book for those in the academic,industrial, governmental, and private sectors of the business world. Itprovides the reader with an insight of how toxicology and chemistryfunctions in the environmental science fields and howthese two subjectsare sused in making concise and clear analysis of chemical agents andcontaminants in the water, soil, and air. The ecotoxicity affects of thesecontaminants are reviewed in great detail to give the reader an insight ofhow environmental pollution affects air, water,and soil and thes livingorganisms in each area.

In short one can soon surmise that this textbookmeets the expectations of the reader and gives the reader adetailed-intellectual background information about environmental toxicologyand chemistry. It is a must read textbook and a perfect guide to obtaininga greater level of comprehension in the scientific fields of toxicology andchemistry. ... Read more

Product Description
In this third edition, the editors have accounted for the numerous changes in protocols for managing poison ingestions and have again provided an indispensable resource for all students of pharmacy and the health sciences on the basic principles of clinical toxicology. The book's unique focus on the fundamentals helps the reader understand why events occur and why a particular treatment is selected. Each chapter presents pertinent information on classes of toxic agents, their common sources and usual methods of intoxication, incidence and frequency of poisoning, mechanisms of action, clinical signs and symptoms of poisoning and management guidance. The text includes illustrative case studies, carefully selected to reinforce the information covered. Each chapter concludes with review questions to further enhance comprehension. ... Read more

Product Description

This is the final volume in a three-volume work that has addressed the scientific methodologies relevant to clinical neurobehavioral toxicology. Volume I focused on basic concepts and methodologies in Neurobehavioral Toxicology, with Volume II focusing on the peripheral nervous system. Volume III attends to what is known about industrial and environmental chemicals, medicines, and substances of abuse and how these agents affect the central nervous system. All substances have the capacity to be toxic, depending on factors that include the physical properties of the chemical or compound, organism related variables, or interaction between the two. These substances on the other hand and as a result of these same factors might be used therapeutically or even recreationally. The difference between medicine, recreational drug, or poison depends often on a careful balance between adverse and intended effects. How to determine that a specified substance has caused harm is emphasized in the present volume by way of case examples and discussion. Illnesses and behavioral variations that compete with toxicant-induced explanations for findings in a given case, as well as the various controversies that can arise around issues of diagnosis and causal determination, are treated comprehensively in this volume.

Product Description
Encompassing 150 articles written by leading scientists in the field, the third edition of General and Applied Toxicology provides a comprehensive and in-depth review of the basic science of toxicology, its specializations, and the application of toxicological knowledge.

This new edition reflects developments within the field that have taken place since the second edition was published in 1999.  These include:  

• New information developed in the areas of both the fundamental and applied aspects of toxicology
• Considerable increase in the development of fundamental information and its applications, refinement of technical methods, advances in mechanistic toxicology, and greater interest in areas of toxicology previously regarded as of limited scope
• Changing approaches to methodological, interpretative, regulatory, and ethical aspects of basic and applied toxicology

General and Applied Toxicology, 3^rd Edition is the first port of call for academic researchers, industrial researchers, regulatory professionals, and advanced students looking for timely and authoritative information in the field. Due to the increase in public and media interest in exposure to toxic substances, this provides an indispensable general reference source for general physicians, lawyers, law enforcement agencies, information resource facilities, and members of the general public. ... Read more

Product Description
Combining the established disciplines of pharmacokinetics (PK), the relationship between drug concentration and time, and pharmacodynamics (PD), the relationship between drug effects and concentration, this handbook examines the relevant relationship between drug effects and time. It provides a systematic overview of how PK is linked to PD, introduces the basic concepts of PK-PD modeling and presents the underlying theory behind it, and discusses the specific aspects of PK-PD modeling for various classes of drugs. ... Read more

Product Description
Univ. of London, U.K. Review questions for the student preparing for an exam. Softcover. Trim size: 9.25 x 6 inches. ... Read more

Customer Reviews (1)

One of several very good IAQ primers
The function of an IAQ primer is to give a reader a sense of the field, without losing any of the depth of the various topic areas.This book does that. Only reason that it does not rate a 5 star rating is that it is now 12 years old, and some of the data is now, well, dated.
The contributors include a few of the current well-respected researchers (besides the editiors Samet and Spengler) including Harriet Burge in Chapter 12 (Indoor Air Pollution and Infectious Diseases) and Bill Cain in Chapter 6(Environmental Tobacco Smoke).
This is still a valuable basic text that helps to give one a nice overview of the complexities of indoor air quality investigation, without as I mentioned above, sacrificing the detail. ... Read more

Product Description
According to the Institute of Medicine (IOM) and U.S. Food and Drug Administration (FDA), "developing new scientific approaches to detecting, understanding, predicting, and preventing adverse events" was a critical path to the future of drug safety. This book brings together a collection of state-of-the-art chapters, written by experts in the drug safety field. It provides information on the present knowledge of drug side effects and their mitigation strategy during drug discovery, gives guidance for risk assessment, and promotes evidence-based toxicology. Each specific area of toxicology relevant for drug discovery is discussed in detail, including theory, experimental approaches, and data interpretation supported by comprehensive up-to-date references. Many chapters provide fascinating case studies, which are of general interest for those who have basic science training and are interested in how chemicals interact with the human body. ... Read more

Product Description
A review of the effects of toxicants on the male and female reproductive systems and discussion of current tests to assess reproductive toxicity. This text reviews normal reproductive function, explains the mechanisms by which toxicants disrupt ... Read more

Product Description
Practical, quick reference guide for thoseinvolved in protecting worker's health.Organized for rapid access, clarity and conciseness.Contents are various chemicals, drugs, insecticides and other compounds.Entries are listed by most familiar names.Each entry contains data such as known-synonyms; aspects of toxicity; Threshold Limit Values; tests; treatment, recomended precautions. Appendix contains extensive bibliography. ... Read more

Customer Reviews (1)

A quitepractical guide
A very practical handbook of occupational toxicology. Althougt published in 1987, it is still very useful to the occupational health professionals. It brings, in alphabetical order, all the toxic chemicals found in theindustrial environment, and all their important features: description,exposure sources, threshold limit, routes of entry, action, signs andsymptoms, diagnosis, treatment, disability and preventive measures. Perhapsyou will need to bring up to date some informations from recent sources,but in this book you will find the main guidelines to understand and act inthe presence of chemical occupational exposure or diseases. ... Read more

Product Description
OCCUPATIONAL, INDUSTRIAL, AND ENVIRONMENTAL TOXICOLOGY quickly provides practicing clinicians with the specific and detailed information they need to cost-effectively diagnose, manage, and treat toxic exposures. It's the only book available that recommends a diagnosis according to a patient's occupation, as well as signs and symptoms. When the patient's history is taken, the clinician uses this book to look up the patient's occupation and environment to learn what agents were most likely exposed, the systemic effects, and the suggested treatment.

The only occupational/environmental medicine book to be organized by occupation.Contains real-world advice on understanding, diagnosing, treating, and referring patients who have been exposed to toxic substances.Presents clinical information with an archive of historical photos from the award-winning Bettmann Art Archive.Contains unique chapters on cybertoxicology, environmental audits, and property transfers.Uses an agent cross-referencing system unique to this reference. ... Read more

Customer Reviews (1)

Unique book describing occupation-specific toxic hazardsThis
The only book of its kind that examines the toxicology of work related illness by occupation. So, a practitioner faced with a patient can look up and read about the toxic hazards that are specific to that patient's job or occupation. This book rated as one of the best by the American Journal of Industrial Medicine ... Read more

Product Description
Deaconess-Nashoba Hospital, Ayer, MA. Guide to rapid assessment and intervention in a poisoning emergency. Provides a full range of toxic emergencies, from substance abuse and drug reactions to chemical exposures, animal bites, and wild plant poisonings. Based on the works of Matthew J. Ellenhorn. Softcover. DNLM: Poisoning--Examination Questions. ... Read more

Product Description
An Indispensable Reference of Air, Soil, and Water PollutantsThis second edition of Environmental Toxicology focuses on the biological and health effects toxins have on living organisms. It also stresses the relationship between human activity and the environment, relating changes in the environment with the changing patterns of human diseases, and exploring the parallels between developing economies and pollution-related health problems.The book deals with a large number of environmental toxicants, discussing their damage process, metabolism (biotransformation), and metabolism, toxicants and their damage process, and environmental, biological, and nutritional factors that may influence toxicity. It also describes several natural defense systems and the mechanisms for detoxification, including endogenous antioxidants and free radical scavenging enzymes on a cellular level. The book continues its comprehensive analysis of EPA Criteria Air Pollutants (SO2, NO2, O3!, CO, particulate matter), and volatile organic compounds, as well as soil and water pollution, and expands the chapters on fluoride, environmental metals and metalloid (lead, cadmium, mercury, nickel, and arsenic), pesticides and related material such as PCBs and dioxins, and their relationship with endocrine disruption (a new chapter) and environmental cancer, offering more insight on the interaction of various chemical agents with DNA.Based on research from nearly 30 years of teaching environmental toxicology and related courses, the author concludes this text with an introduction to ecological risk assessment and its role in regulation and policymaking. ... Read more

Product Description
Written by internationally recognized scientists from academic, industrial, and governmental sectors, Inhalation Toxicology, Second Edition details the methods and materials used in the theoretical and applied aspects of inhalation toxicology. The editors emphasize the relationship between the respiratory system and toxicology of inhaled substances and examine methods and measurements for improving our understanding of the basic mechanisms of effects.

The book delineates key issues in the field such as regulatory aspects of exposure and testing, testing equipment and methods, biomarkers, pathology, allergies and immunology, irritation of the respiratory tract, and risk assessment. It covers the inhalation of bioaerosols and toxins, ranging from anthrax to household molds as well as genomics, proteomics, and low-level exposure toxicants such as tobacco smoke and chemical warfare agents. Highlights include coverage of the Acute Exposure Guidelines and Emergence Response Guidelines and recent changes in the European and American guidelines for testing procedures.

The book focuses on key issues associated with airborne substances and provides critical reviews of the latest advances. Presenting sophisticated concepts in a readable, accessible format, the book distills the latest information into practical knowledge. ... Read more

Product Description
Adapting modern advances in analytical techniques to daily laboratory practices challenges many toxicologists, clinical laboratories, and pharmaceutical scientists. The Handbook of Analytical Therapeutic Drug Monitoring and Toxicology helps you keep abreast of the innovative changes that can make your laboratory - and the studies undertaken in it - a success. This volume simplifies your search for appropriate techniques, describes recent contributions from leading investigators, and provides valuable evaluations and advice.Discover how to use non-invasively obtained specimens to your best advantageThe text features alternative biological specimens such as hair, meconium, saliva, sweat, and vitreous humor, which are not extensively used because they require more sensitive procedures than other biological specimens. How to overcome these limitations is a major topic of the handbook. Experts describe basic principles of innovative techniques and detail how they can be adapted to analyzing alternative biological specimens. The evaluations of the pros and cons of various advances in immunodiagnostics and how they apply to analytes will help you determine their suitability to your own laboratory. The Handbook of Analytical Therapeutic Drug Monitoring and Toxicology helps you make the most of innovative procedures that will open the doors to productive laboratory practices. ... Read more

Product Description
A clear, straightforward resource to guide you through preclinical drug development

Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic,comprehensive reference to prioritizing and optimizing leads, toxicity, pharmacogenomics, modeling, and regulations. This single definitive, easy-to-use resource discusses all the issues that need consideration and provides detailed instructions for current methods and techniques.

Each chapter was written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor, with more than thirty years' experience working with pharmaceutical and biotechnology companies, carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear.

Among the key topics covered are:
*

In vitro mammalian cytogenetics tests
*

Phototoxicity
*

Carcinogenicity studies
*

The pharmacogenomics of personalized medicine
*

Bridging studies
*

Toxicogenomics and toxicoproteomics

Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage.

This is a hands-on guide for pharmaceutical scientists involved in preclinical testing,enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin. ... Read more

Product Description

Examines endocrine toxicology’s increased importance in environmental safety issues due to legislative directives established over the past ten years.

With contributions by international experts in academia, chemical manufacturing, government research laboratories, regulatory agencies, and private consulting, this guide explores the potentially damaging influence of environmental agents on the endocrine system.

Covering all principal areas of EPA concern, Endocrine Toxicology, Third Edition provides:

• putative endocrine disruptors and mechanisms of endocrine toxicity
• the history and status of the regulatory process
• mechanisms of toxic effects in various hormonal systems
• comparisons of the endocrine responses in humans, livestock, and wildlife
• testing methods in mammalian, fish, avian, and amphibian models
• valuable insight into the approaches of various personnel in the field, including: government officials who make and oversee policy; scientists in charge of development and validation of testing methods; basic researchers who identify toxic mechanisms; and manufacturers responsible for environmentally benign product certification