Product Description
Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflamatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways.
Thus, research was undertaken to find a safer way to transfer genes to patients without jeopardizing the safety of the patient. And so non-viral vectors were discovered. This volume presents the various non-viral vectors currently under development. Although not methodologically oriented, it will provide the necessary details behind the development of the vectors. This information will prove useful to both researchers and clinicians.

Key Features
* Presents state-of-the art developments of nonviral vectors as tools for modern molecular medicine
* Covers all types of nonviral vectors, from molecular structure to therapeutic application
Provides a comprehensive review of synthetic vectors
* Includes contributions from major investigators and leading experts in the field ... Read more

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This volume, the last in the excellent Blood Cell Biochemistryseries, focuses specifically on gene therapy in the hematopoieticsystem; its applications, aspirations and problems, and providesinsight as to how the hematopoietic system may be considered as atarget in therapy of acquired and inherited disease of other tissues. ... Read more

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This first comprehensive guide to the novel field of gene therapy in the skin provides insight into the basic principles and methods of gene transfer into the skin and its applications. It enables the understanding of possibilities and implications such as immunization and treatment as well as safety aspects. Gene therapy in dermatology is the avantgarde of a new field in science with a great future for human health. ... Read more

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This econometric study covers the latent demand outlook for gene therapy across the prefectures and cities of Japan. Latent demand (in millions of U.S. dollars), or potential industry earnings (P.I.E.) estimates are given across some 1,000 cities in Japan. This statistical approach can prove very useful to distribution and/or sales force strategies. Using econometric models which project fundamental economic dynamics within each prefecture and city, latent demand estimates are created for gene therapy. This report does not discuss the specific players in the market serving the latent demand, nor specific details at the product level. The study also does not consider short-term cyclicalities that might affect realized sales. The study, therefore, is strategic in nature, taking an aggregate and long-run view, irrespective of the players or products involved.

This study does not report actual sales data (which are simply unavailable, in a comparable or consistent manner in virtually all of the cities in Japan). This study gives, however, my estimates for the latent demand, or the P.I.E., for gene therapy in Japan. It also shows how the P.I.E. is divided and concentrated across the cities and regional markets of Japan. ... Read more

Product Description
Offers current data on delivery systems and therapeutic strategies, gene expression and detection, and disease targets and therapeutic strategies. Presents results and prospects in gene therapy clinical trials, other cell-based therapies and trials, and regulatory issues. Topics include optimization of non-viral gene therapeutics, gene therapy for cancer, and DNA vaccines. ... Read more

Customer Reviews (1)

Exactly as advertised
Book arrived within the time period indicated by the seller. Mint condition, just like the seller stated. Will buy again from seller. ... Read more

Product Description
Protocols for Gene Transfer in Neuroscience Towards Gene Therapy of Neurological Disorders Edited by P. R. Lowenstein University of Manchester, UK and L. W. Enquist Princeton University, USA The brain and the cells that compose it have always presented unique barriers to any kind of outside interventions, including drug delivery, surgical procedures and the genetic manipulation of cells. However, these barriers are now being bypassed by the new technology of gene delivery. Protocols for Gene Transfer in Neuroscience is the first practical guide to gene delivery, providing over 150 easy to follow, step-by-step protocols, together with troubleshooting hints and the theoretical background needed for neuroscientists to understand, adapt and expand the technology as needed. Written by a team of international expert neuroscientists, geneticists, molecular biologists and biochemists, Protocols for Gene Transfer in Neuroscience describes the latest techniques from the top gene-delivery labs, ranging from physical transfection techniques, through the use of a wide range of viral vectors, to retrovirally transduced cell and bone marrow transplantation. Several variations of a single protocol are given, thus demonstrating how different labs have solved a common problem in different ways. The protocols are also indexed and cross-referenced so that an investigator can find all the details required for a particular problem. ... Read more

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In recent years fundamental progress has been made in understanding the molecular mechanism of the pathogenesis of diseases in different areas of medicine.Additionally, the development of a multitude of gene transfer techniques allows to genetically manipulate almost all cells of the body. To use genes instead of their products for therapy is an entirely new concept in medicine, commonly termed "gene therapy". Gene therapy is still in its infancy. The task is enormous because most targets of gene therapy are diseases for which no curative therapy exists. Seeing the large number of attractive gene therapy approach, there is little doubt that it will find a firm place in the clinic.The difficulty in delivering genes to the right place and effectively controlling their expression are outlined in the first section of this book, which considers both viral and physical methods of gene delivery. The second part describes gene therapy of single gene defects, like cystic fibrosis and familial hypercholesterolemia. After a chapter of gene marking part four covers important aspects of gene therapy of cancer. ... Read more

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Genetics and Gene Therapy shows the wide range of the debate and the very real significance that genetics and its associated developments have for human beings, individually and collectively. Few areas of science and medicine have resulted in the volume of academic and popular literature as has genetics. The so-called revolution in understanding of the causes of disease states, and even behavioural traits, has focussed public attention on the influence of genes in making us what we are. Rapidly, however, the potential benefits of such understanding were overtaken, in the public mind at least, by the question of the possible (negative) implications of genetic knowledge and associated technologies. The chapters in this volume show just how wide-ranging concern has become, ranging from regulation to cloning, with the fear of discrimination in between. Part One begins with a range of general discussions of about the genetic enterprise itself, followed by consideration of some specific questions. Part Two then addresses cutting edge debates in genetics. ... Read more

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Distinguished scientists provide an overview of the molecular pathology of human disease. Each chapter provides an analysis of the molecular biological approaches to individual diseases, such as leukaemia, cardiovascular disease and cancer, and includes a ... Read more

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As human gene therapy becomes a clinical reality, a new era in medicine dawns. Novel and innovative developments in molecular genetics now provide opportunities to treat the genetic bases of diseases often untreatable before. Somatic Gene Therapy documents these historical clinical trials, reviews current advances in the field, evaluates the use of the many different cell types and organs amenable to gene transfer, and examines the prospects of various exciting strategies for gene therapy. ... Read more

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In the last decade, scholars throughout the world have begun to break the conversational taboo surrounding human genetic engineering.This book will contribute to this important discussion by providing an up-to-date summary and analysis of key issues in human germline gene therapy with the intention of laying the foundation for further debates and public policy decisions. Without denigrating or glorifying the new technology, the authors offer a sober assessment of its promises and delusions, its dreams and nightmares by presenting potential benefits and harms of human germline gene therapy from a scientific, ethical and political standpoint. The first part of the book provides a thorough and well-referenced introduction to the science underlying gene therapy, including a review of basic genetic concepts for non-molecular biologists, current and future methods for genetic testing, alternatives to human germline gene therapy, current gene transfer techniques, and the technology which would be required before human germline gene therapy could be attempted. The second part of the book considers the possible medical, evolutionary, economic, military, and psychosocial benefits and harms of human germline gene therapy and also considers the procedure from the perspective of human rights, justice, and interference with nature.The book concludes with some public policy recommendations and stresses the need for international cooperation in developing and implementing human germline gene therapy policies. ... Read more

Product Description
This econometric study covers the outlook for gene therapy in Asia & Oceana. For each year reported, estimates are given for the latent demand, or potential industry earnings (P.I.E.), for the country in question (in millions of U.S. dollars), the percent share the country is of the region and of the globe. These comparative benchmarks allow the reader to quickly gauge a country vis-a-vis others. Using econometric models which project fundamental economic dynamics within each country and across countries, latent demand estimates are created. This report does not discuss the specific players in the market serving the latent demand, nor specific details at the product level. The study also does not consider short-term cyclicalities that might affect realized sales. The study, therefore, is strategic in nature, taking an aggregate and long-run view, irrespective of the players or products involved.

This study does not report actual sales data (which are simply unavailable, in a comparable or consistent manner in virtually all of the countries in Asia & Oceana). This study gives, however, my estimates for the latent demand, or the P.I.E. for gene therapy in Asia & Oceana. It also shows how the P.I.E. is divided across the national markets of Asia & Oceana. For each country, I also show my estimates of how the P.I.E. grows over time (positive or negative growth). In order to make these estimates, a multi-stage methodology was employed that is often taught in courses on international strategic planning at graduate schools of business. ... Read more

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This book focuses primarily on the development of effective gene therapy approaches for HIV infection, including the improvement of gene transfer vectors, procedures for the ex-vivo manipulation and transduction of T-lymphocytes and hematopoietic stem cells, and preclinical testing of HIV inhibition strategies. It provides a balanced perspective of the many accomplishments in this field as well as the problems which need to be solved in order to develop safe and effective therapies which benefit persons with HIV infection. ... Read more

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Gene transfer technology is a powerful tool for increasingour understandingof brain functions. It is also the basisof gene therapy, which is nowtechnically possible for thecorrection of many human diseases, including severaldisorders of the nervous (and muscular) system such asAlzheimer's disease, Parkinson's disease, and dystrophy.This volume,which contains the proceedings of a symposiumof the Fondation Ipsen, provides a unique view of the stateof the art on different transgenes, vectors, target cells,and clinical applications related to the nervous system. ... Read more

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Gene Therapy Technologies, Applications and Regulations From Laboratory to Clinic Edited by Anthony Meager Division of Immunobiology, The National Institute for Biological Standards and Control, South Mimms, UK The development of gene-based technologies has been rapid over the past decade and has consequently resulted in a surge of interest in human gene therapy, the deliberate transfer of genes to somatic cells to cure or alleviate disease symptoms. Hundreds of clinical protocols involving variously designed vectors for efficient gene transfer have been developed. However, the use of such complex 'gene medicines' containing potentially heritable genes has raised numerous concerns regarding quality, efficacy and safety. Encompassing recent developments in the field and addressing current concerns this book:
* surveys many of the current technologies for preparing vectors for use in gene therapy protocols
* reviews the application of gene-mediated therapies to a range of medical conditions
* considers the regulatory aspects of gene therapy including product quality and safety requirements
* appraises the transfer of technologies from laboratory to clinic with regard to the attendant requirements and facilities for:
* good laboratory practice (GLP) conditions in the R&D laboratory
* large-scale production methods and good manufacturing practice (GMP)
* current in-process and final product testing

Written by international experts knowledgeable about many aspects of human somatic gene therapy, this book will be an essential guide for those embarking on gene therapy technologies relevant to specifications of production and testing of products (and procedures) required to meet existing regulations, including quality, efficacy and safety considerations. ... Read more

Customer Reviews (1)

A new look at gene therapy.
Please visit the editor's website at http://www.kjscanlon.com/ . You will find out more about Dr. Kevin Scanlon and his work. I found many interesting resources for gene therapy. ... Read more