Product Description
Mimicking natural biochemical processes, click chemistry is a modular approach to organic synthesis, joining together small chemical units quickly, efficiently and predictably. In contrast to complex traditional synthesis, click reactions offer high selectivity and yields, near-perfect reliability and exceptional tolerance towards a wide range of functional groups and reaction conditions. These ‘spring loaded’ reactions are achieved by using a high thermodynamic driving force, and are attracting tremendous attention throughout the chemical community. Originally introduced with the focus on drug discovery, the concept has been successfully applied to materials science, polymer chemistry and biotechnology.

The first book to consider this topic, Click Chemistry for Biotechnology and Materials Science examines the fundamentals of click chemistry, its application to the precise design and synthesis of macromolecules, and its numerous applications in materials science and biotechnology.  The book surveys the current research, discusses emerging trends and future applications, and provides an important nucleation point for research.

Edited by one of the top 100 young innovators with the greatest potential to have an impact on technology in the 21^st century according to Technology Review and with contributions from pioneers in the field, Click Chemistry for Biotechnology and Materials Science provides an ideal reference for anyone wanting to learn more about click reactions.

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Customer Reviews (1)

Timely collection of a new front
Click chemistry as a concept has been received well enough in terms of ever-increasing publications. Applications mostly point to material sciences and biotechnology where beautiful examples were demonstrated (the topics of the book). On industrial level click chemistry has yet to offer anything practically important. Neither has it afforded much in pharmaceutical world which was initially targeted. Some small libraries and screening work have been published in search of enzyme inhibitors using click chemistry. It is possible that there is large body of work not disclosed by industry for IP reasons.

These should not deny the concept and some very good reactions hard to come by in organic chemists' eyes. Like anything else, there has to be a period in which theories, examples, commercial reagents are getting ready in place - and workers would doubt, hesitate, then start to try it out, overcome some difficulties, and finally like and adopt it. This will take much longer for intended biotechnology scientists than for professional chemists. The book comes in a very timely fashion and may help to significantly shorten this period.
The 411-page book has the traditional "Wiley-quality".Frontier research groups describe their own work in 16 loosely connected chapters and give a broad picture of "current" status of the application of click chemistry in two fields: biotechnology and material science. Expect 16 reviews or accounts in very recent time - perfect for one to survey and enter the field. Readers may find it useful in two ways. They may adopt the applications directly in their closely related work. Or they may be excited by the elegance of the chemistry and adopt the chemistries in their own fields. After all, it is a very, very good tool. Some readers may turn out to be interested in certain chapters, not the others, largely due to the nature of the chemistry as a tool and therefore the large scope it can be used. The index appears very thin and may be hard to use. The literature does not cover the patent world.

One would realize how fast the field is developing if I say that many significant progresses have already taken place since April 2009, the Preface date by the Editor Joerg Lahann. It is necessary to follow the most current publications in major journals to keep up with the field.

Click chemistry is not equal to Cu(+) catalyzed triazol formation although literature centers on it. At least two types of Cu-free exist, which comforts many workers in toxicity concerns. Another click reaction, ene-thiol reaction, may find the best practical use in industry.

Running a click reaction is not as easy as a piece of cake. Actually one may need quite some tweaking in starting trials, particularly in catalyst and solvent selection. There are very good reviews detailing all these aspects. Once you get it working for you, click chemistry can be very rewarding and productive.

In early days, one had to make all the reagents themselves before coming to the final "click". No doubt it did not help those who were not familiar with organic synthesis but could potentially be interested and would not mind in "clicking". Last several years has seen increasing reagent offering from a wide range of vendors, both domestic and international. One would see more and more reagents available in "clickable" forms: biotin, fluorophore, quenchers, amino acids, carbohydrate, PEG, nucleosides for biotechnology, and many precursors, dendrons, intermediates for material science. There are even more for thiols and terminal alkenes.
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Product Description
Written by exceptionally experienced experts from one of the world's major biotech regions, the Heidelberg area, the authors come from academia, such well-known research centers as the German Cancer Research Center, and biotech companies.
A very detailed introduction to the fundamentals in molecular and cell biology is followed by an overview of standard techniques applied in molecular biotechnology -- including chromatography and electrophoresis, cloning techniques, gene expression systems, immunological methods, labeling of proteins and in situ-techniques, microscopy and laser systems. The third part then focuses on the key topics of molecular biotechnology, ranging from functional genomics, proteomics and bioinformatics to drug targeting, recombinant antibodies, structural biology, gene therapy and knock mice. The whole is rounded off by a section on biotechnology in industry dealing with patenting issues, company foundation and market opportunities.
On over 800 pages this book provides students and professionals in life sciences, pharmacy and biochemistry with all they need to know about molecular biotechnology. ... Read more

Product Description
An exhaustive review on all things algae would require a multi-volume encyclopedic work. Even then, such a tome would prove to be of limited value, as in addition to being quite complex, it would soon be outdated, as the field of phycology is full of continual revelations and new discoveries.

Algae: Anatomy, Biochemistry, and Biotechnology offers students and researchers in phycology a more practical and useful approach. Instead of trying to offer a little bit of everything, the authors concentrate on highlighting especially interesting and illuminating topics, with the idea of inciting the sort of wonder and curiosity in undergraduate and post-graduate students that will encourage further outstanding work.

The chapters can be read in progression to provide structure to a semester, or each can be read on its own as a self-contained essay to supplement other work.

Written and designed for those with a general scientific background, the book covers freshwater, marine, and terrestrial forms. Its early chapters present an overview of the classification of the algae; these chapters are followed by reviews of life cycles, reproductions, and phylogeny, providing a conceptual framework that promotes a deeper understanding of more complex topics. Levels of organization are examined from the subcellular, cellular, and morphological standpoints, leading to discussions involving physiology, biochemistry, culture methods, and finally, the role of algae in human society. New findings are provided to demonstrate that the world of algae is still ripe with discovery for those students who keep their eyes and their minds active and open.

Algae: Anatomy, Biochemistry, and Biotechnology stands as a hybrid, offering something of a cross between a typical review and a descriptive monograph. The work makes it possible for students to visualize and compare algal structure. It also supplies carefully selected literature references that direct researchers to an abundance of precise details from original sources. ... Read more

Product Description
The biopharmaceutical industry has become an increasingly important player in the global economy, and the success of these products depends on the development and implementation of cost-effective, robust and scaleable production processes. Bioseparations-also called downstream processing- can be a key source of competitive advantageto biopharmaceutical developers. Process Scale Bioseparations for the Biopharmaceutical Industry brings together scientific principles, empirical approaches, and practical considerations for designing industrial downstream bioprocesses for various classes of biomolecules.

Using clear language along with numerous case studies, examples, tables, flow charts, and schematics, the book presents perspectives from experienced professionals involved in purification processes and industrial downstream unit operations. The authors provide useful experimental design strategies and guidelines for developing application-specific process scale bioseparations. Chapter topics include harvest by centrifugation and filtration, expanded bed chromatography, protein refolding, modes of preparative chromatography, methodologies for resin screening, membrane chromatography, protein crystallization, viral filtration, ultrafiltration/diafiltration, implementing post-approval downstream process changes for an antibody product, and future trends.

Ideal for both new and experienced scientists in the biopharmaceutical industry and students, Process Scale Bioseparations for the Biopharmaceutical Industry is a comprehensive resource for all topics relevant to industrial process development. ... Read more

Customer Reviews (1)

Great Industrial Supplement to Scopes
This is a nice book for those in the industry or students wanting to see how the theories presented in Scopes' "Protein Purification" (or similar) are implemented at larger scales. The book is organized topically so you can jump from one to the other out of order if you like. The chapters on "Modes of Preparatory Chromatography" (esp. the treatment of HIC), "Screening of Chromatographic Stationary Phases", and "Protein A Affinity Chromatography..." and "Polishing Methods..." are particularly well executed. You don't get the sense that this book is just a marketing channel for some company and their products, which is more than I can say for some of the other books out there on the subject. Good buy. ... Read more

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The essays in this volume apply philosophical analysis to address three kinds of questions: What are the implications of genetic science for our understanding of nature? What might it influence in our conception of human nature? What challenges does genetic science pose for specific issues of private conduct or public policy? ... Read more

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In the United States today, the human body defines a lucrative site of reusable parts, ranging from whole organs to minuscule and even microscopic tissues. Although the medical practices that enable the transfer of parts from one body to another most certainly relieve suffering and extend lives, they have also irrevocably altered perceptions of the cultural values assigned to the body.

Organ transfer is rich terrain to investigate& mdash;especially in the American context, where sophisticated technological interventions have significantly shaped understandings of health and well-being, suffering, and death. InBodies, Commodities, and Biotechnologies, Lesley Sharp probes the ideological assumptions underlying the transfer of body parts, the social significance of donors' deaths, and the medico-scientific desires surrounding complex forms of body repair. Sharp also considers the experimental realm, in which nonhuman species and artificial devices present further opportunities for recovery and for controversy.

A compelling scientific investigation and social critique,Bodies, Commodities, and Biotechnologies explores the pervasive, and at times pernicious, practices shaping American biomedicine in the twenty-first century.

Product Description
The second edition of Immobilization of Enzymes and Cells serves as an update as well as a compliment to the first edition. This volume now includes simple protocols for the immobilization of enzymes and cells that could be useful for application at industrial scale, novel protocols for immobilization in the future, and new chemical reactors able to overcome the limitations of a number of immobilized derivatives. ... Read more

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This book is a comprehensive manual to allow both the novice researcher and the expert to set up and carry out quantitative PCR assays from scratch. However, this book also sets out to explain as many features of qPCR as possible, provide alternative viewpoints, methods, and aims to simulate the researchers into generating, interpreting, and publishing data that are reproducible, reliable, and biologically meaningful ... Read more

Customer Reviews (4)

Real Time PCR bible
This book fills a large gap in the literature. I wish there were more like that.

Jonas Blomberg

Reference book
This is a very good reference book for my Molecular Lab.Every Molecular lab should have this book.

A-Z of quantitative PCR
Very complete book, containing practical exemples of calculations and solutions for the main issues faced when running quantitative PCR. Excelent daily manual.

qPCR methods
Book arrived promptly and in great shape. Disappointed there was not coverage of one-step qPCR. ... Read more

Product Description

Biotechnology offers one of the most economical and environmentally benign methods of air pollution control for industrial and municipal airstreams. Volatile organic and inorganic odorous compounds from various industries are emitted in large quantities and create hazards to the ecosystem and health effects to humans. Thus, the demand for odor and air pollution control systems that provide nuisance-free, breathable air is constantly growing.

An international board of authors from universities, research institutes, and industries describe various biotechnological methods ranging from laboratory, to pilot evaluation and to full-scale process implementation. Topics include bioprocesses for the treatment of odors and air pollutants in wastewater treatment plants, rendering plants, chemical production facilities, and food and flavor manufacturing facilities. In addition to the basic microbiological and engineering aspects, the design, modeling and control of bioreactors are also presented.

Product Description
A definitive guide to the development, application, and use of biopesticides as a complementary or alternative treatment to chemical pesticides. Biopesticides: Use and Delivery brings together for the first time all the latest advances in the control of insects, plant diseases, and weeds with biopesticides. Coverage extends from the science and technology of biofungicides, bioinsecticides, and bioherbicides to detailed management protocols. The many leading experts writing here review their development, mode of action, production, delivery systems (formulations), and future market prospects. In addition, experts from both government and industry discuss current registration requirements, including time frame and costs of registration, and compare these with the registration requirements for conventional pesticides.



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Continued advances in biotechnology have driven forward the harnessing of micro-organisms and plants to help protect our fragile environment from the impact of human activity in increasingly targeted yet diverse ways. Environmental Biotechnology provides a broad overview of the subject, focusing on how biotechnological techniques are applied to solve environmental problems, rather than giving detailed explanations of the techniques themselves. Opening with an overview of environmental biotechnology, and a review of the key aspects of microbiology upon which the field is based, the book goes on to explore the diverse way in which biotechnology is applied to tackle environmental problems and issues, from monitoring of the environment and treatment of waste, to the removal of pollutants and extraction of oil and minerals. The book closes with a discussion of the ways in which future advances in biotechnology are likely to be harnessed to address current and emerging issues and problems in increasingly effective and powerful ways.Capturing the current excitement in a field reinvigorated by advances in genetic manipulation, and emerging genomic and proteomic technologies, Environmental Biotechnology is the perfect resource for any student needing to develop a sound understanding of biotechnology, and the diverse ways it can be applied to address important environmental issues.Online Resource Centre - Figures from the book available to download, to facilitate lecture preparation - Library of web links cited in the book, to give students ready access to these additional resources ... Read more

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A groundbreaking new exploration of the promises and perils of biotechnology -- and the future of American society.

Biotechnology offers exciting prospects for healing the sick and relieving suffering. But because our growing powers also enable alterations in the workings of the body and mind, they are becoming attractive to healthy people who would just like to look younger, perform better, feel happier, or become more "perfect."

This landmark book -- the product of more than sixteen months of research and reflection by the members of the President's Council on Bioethics -- explores the profound ethical and social consequences of today's biotechnical revolution. Almost every week brings news of novel methods for screening genes and testing embryos, choosing the sex and modifying the behavior of children, enhancing athletic performance, slowing aging, blunting painful memories, brightening mood, and altering basic temperaments. But we must not neglect the fundamental question: Should we be turning to biotechnology to fulfill our deepest human desires?

We want better children -- but not by turning procreation into manufacture or by altering their brains to gain them an edge over their peers. We want to perform better in the activities of life -- but not by becoming mere creatures of chemistry. We want longer lives -- but not at the cost of becoming so obsessed with our own longevity that we care little about future generations. We want to be happy -- but not by taking a drug that gives us happy feelings without the genuine loves, attachments, and achievements that are essential to true human flourishing. As we enjoy the benefits of biotechnology, members of the council contend, we need to hold fast to an account of the human being seen not in material or mechanistic or medical terms but in psychic, moral, and spiritual ones. By grasping the limits of our new powers, we can savor the fruits of the age of biotechnology without succumbing to its most dangerous temptations.

Beyond Therapy takes these issues out of the narrow circle of bioethics professionals and into the larger public arena, where matters of this importance rightly belong.

Customer Reviews (6)

Against the American Brain
I can do no better than quote Carl Elliott writing in Slate:

"As much as it pains me to admit that anything worthwhile could come from a council appointed by the Bush administration, Beyond Therapy is a remarkable document: gracefully written, thoroughly researched, ideologically balanced, and philosophically astute. It will be a benchmark for all future work on the topic."

Garbage of A THEOCRAT
Leon R. Kass, M.D., P.h.D., is chairman of the 'President' George W. Bush's Council on Bioethics. This book was intelligently written without any reference to religion but the whole underlying message was "Do not touch Gods property even if it means healing the sick." These religious fundamentalists will do anything to STUNT us in our pursuits of happiness. This guy is for KEEPING PARALYZED PEOPLE PARALYZED. "Dr." Kass is for KEEPING AMPUTEES AMPUTATED. He's for KEEPING the depressed and suicidal DEPRESSED AND SUICIDAL. Ill spare you the bull and say what Dr. Kass really wants to say - "I want you to follow Jesus with all your heart no matter how much pain and suffering you are in. If God made you depressed than thats how you should be. If God made you paralyzed then thats how you should be. If you are miserable in your existance then thats obviously how God wants you to be and thats how you will be with our new conservative laws that will effectively ban progress to help people". For this is the ONLY real argument you can use to support the banning of progress designed to help humans. - He wants everyone to follow the 'divine' rule of sanctity of life, not quality of life - an ugly ethic for a very stupid man.

A first - rate consideration of the human condition
This work goes well beyond the framework of aPresident's Commission Report to be an informative and challenging inquiry into the current state of biotechnological research , and its philosophical implications. It considers in separate chapters the work that is being done to increase human performance- level in sport, to as it were `produce better children', to prolong and increase the quality of human life, and to bring us closer to ` human happiness'. The tone of this work is measured and responsible, the information presented that which has been weighed and tested. Above all in considering each of these areas the debate is carried on with a broad- minded and deep consideration of the meaning of what it is to be human. Thus there is neither the ` gung-ho' utopianism of certain kinds of over- optimistic futurists, nor the paralyzing pessimism of various over- protectors of their own narrow conceptions of the human past. In each of the areas a balanced discussion provides the reader, not with definite and final answers to the problems and possibilities raised, but with suggestions for thought.
We have long since learned that scientific and technological advances usually have their ` price' in one way or another. Here trade-offs in the various areas are made explicit. The new technology which enables us to decide upon the sex of the child has already let to tremendous imbalances in among other areas, the populations of China and India. The prolonging of life is in many cases the prolonging of what seems to be senseless suffering. The ability to enhance moods through chemical means raises the question of what happiness means when it is devoid of the context of human relationship. The possibility of prolonging life indefinitely raises the question of what this might mean for future generations , and the whole spirit of renewal that the birth of a new generation gives to the world.
Leon Kass a moral thinker of the first order, and the director of this enterprise has often been unjustly accused of being a ' super- conservative' and even' fundamentalist'. Such nonsense does not do justice either to Kass impressive scholarly enterprise, or to the great human feeling and consideration with which he approaches these subject. It seems to me that his position is much closer to that of what might be called a traditional liberal meliorist, who is looking to see how the human condition can be improved without those improvements leading to its radical undermining. His understanding in this sense of the place of the family and of human relations in the good life, and in happiness starkly contrast him with those ivory- tower ` transhumanists' and ` cyber- champions' who would replace mankind with their own solipsistic minds.
This is an important work not for its definite conclusions but for the serious contribution it makes to the ongoing quest of humanity to understand itself and define and realize its varying conceptions of the good life.

A Fundamentalist Christian's View of Biotechnology
This book is just Leon Klass's latest treatise on all the possible (but not necessarily probable) negative aspects of biological research and progress.

Leon Klass was appointed by George W. Bush as his "Bioethics" committee board chairman - and Leon quickly filled the board with other right-wing christian fundamentalists.To assuage concerns that the board was just a group designed to rubber stamp Bush's foregone conservative opinions he added Dr. Elizabeth Blackburn to the board - a well known scientist out of UC Berkeley.

When it became clear that Dr. Blackburn was too vociferous in her defense of the many benefits to humanity of gene therapy, genetic engineering, stem cell research, etc. - Leon Klass fired her from the board.

Leon Klass is well known for his long history of anti-biotechnology diatribes - including one in which he extols the virtues of a short life (saying that people who want a longer, healthier life are greedy and devaluing the experience of life).

If you choose to read this book - be sure to balance the opinions of this extreme Right fundamentalist - with some modern researchers and ethicists - such as Gregory Stock (UCLA), and John Brockman (see the book The Next Fifty Years : Science in the First Half of the Twenty-first Century).

If you care about helping anyone with Cancer, Alzheimers, Diabetes - or any other serious disease that could potentially be helped by stem cell treatments - you probably won't want to adopt the views of Leon Klass.If Leon Klass' opinions continue to be put into law (as was the Stem Cell ban) progress will slow to a crawl in the US biotech industry and many people will die early deaths due to delayed treatments.

The essential reader on bioethics
Comprehensive bodyof work detailing the current debates in biotech ... Read more

Product Description

Presented from the perspective of the biotech industry, this laboratory handbook/textbook reference gives a systematic, understandable, and practical introduction to fundamental laboratory methods and provides a foundation upon which students can build a career in the lab. The authors balance background and theory with practical information, drawing material from many sources: analytical chemistry texts, molecular biology manuals, industry standards, government regulations, manufacturer and supplier information, and the useful laboratory “lore” that is part of the industry’s oral tradition.  The Modern Biotechnology Industry:  A Broad Overview, The Business of Biotechnology:  The Transformation of Knowledge into Products, Pharmaceutical/Biopharmaceutical Products, Introduction to Product Quality Systems, Biotechnology and the Regulation of Food and Medical Products, Documentation, the Foundation of Quality, Quality Systems in the Production Facility, Quality Systems in the Laboratory, Introduction to a Safe Workplace, Working Safely in the Laboratory: General Considerations and Physical Hazards, Working Safely with Chemicals, Working Safely with Biological Materials, Basic Math Techniques, Proportional Relationships, Relationships and Graphing, Descriptions of Data (Descriptive Statistics),Introduction to Quality Laboratory Measurements, Tests and Assays, Introduction to Instrumental Methods and Electricity,The Measurement of Weight, The Measurement of Volume, The Measurement of Temperature, The Measurement of pH, Selected Ions and Conductivity,  Measurements Involving Light A. Basic Principles and Instrumentation, Introduction to Quality Laboratory Tests and Assays, Measurements Involving Light B. Applications and Methods, Preparation of Laboratory Solutions A: Concentration Expressions and Calculations, Preparation of Laboratory Solutions B. Basic Procedures and Practical Information, Solutions:  Associated Procedures and Information, Laboratory Solutions to Support the Activity of Biological Macromolecules, Culture Media for Intact Cells, Introduction to Filtration, Introduction to Centrifugation, Introduction to Bioseparations, Computers: An Overview, Data Handling with Computers, Applications of the Internet to Biotechnology. Itended for those interested in learning the basics of laboratory methods for biotechnology

Customer Reviews (4)

Informative
This book is a great resource. I plan on using it for a reference.

It is a little dry and unengaging.

It has many important facts and much useful information

can't live without
This book is a necessity for biotech students and the one I purchased was in excellent condition - I won't ever part with it though!

Review:
This is a required college textbook for my daughter.I'll try and remember to let you know if she passes the class.

A Keystone For The Laboratory
When I first started work in a lab as an undergrad, I would often learn of crucial tricks after I had already messed up a procedure and lost an hour or more of work. It's ironic how dependent molecular biologists are on that most ancient means of communication: oral tradition.

When I took a biochem lab, I was introduced to the Seidman and Moore text, which is a fantastic teaching source. For the beginner, this book has chapters on basic units of measurement and mathematics, laboratory organization and regulation (including the government bodies which oversee lab safety), writing standards, and web etiquette. No stone is unturned! Even after one gets the basics mastered, this book has tables on plastics and buffers, showing how they react to heat, light, and other critical data--my biochemistry instructor was even suprised by some of the information on plasticware! This is a companion for one's career in the lab. ... Read more

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This book examines the current challenges and future prospects for agricultural biotechnology from the perspectives of academic, industrial, and governmental research scientists. ... Read more

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Experienced practitioners present detailed accounts of a wide variety of techniques using supercritical fluids. These range from the supercritical fluid extraction methods for numerous compounds to the ninhydrin staining of fingerprints on checks and banknotes-and from the detection of impurities in pharmaceuticals to a wide variety of applications throughout environmental and food science, and across analytical, clinical, and medicinal chemistry. Detailed step-by-step instructions enable users to apply these essential techniques successfully the first time and include modifications that permit their effective adaptation to novel experimental or process conditions. Versatile and comprehensive, Supercritical Fluid Methods and Protocols offers both novice and experienced investigators and laboratory analysts powerful tools thatenablesuccessful biological and bioprocess analyses and optimization today. ... Read more

Product Description
* The first book to provide a simple and practical means of valuing biotech companies
* The book begins with a short history of the biotechnology industry; this is important as although it is about 30 years old, the first company went public only in 1996, so it is possible to plot the course of investment waves and dips
* It examines the European industry and its evolvement, and draws parallels between the similarities and differences between that and the US
* Looks at the various companies which make up the biotech industry (therapeutic; life sciences; and the medical technology company) and gives tools for the investor to properly evaluate them
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Customer Reviews (1)

very difficult to evaluate a biotech's prospects
Keegan tries his best with a very difficult subject. The fundamental problem is, as he says, "there is no obvious or accepted way of applying valuation in the biotechnology industry". It has to do with the complexity of the designed drugs or therapies, and the complexity of responses from a set of human test subjects.

Given these hurdles, the book does an admirable job. Keegan gamely walks us through how the Capital Asset Pricing Model (CAPM) might be applied to a biotech, in no small way to get a Net Present Value. A decision tree method is given, that might prove useful to some biotechs.

His analysis cannot be faulted, so long as you always keep in mind the assumptions upfrontly presented in the text. ... Read more

Product Description
Gives instructions for and explains the principles behind a variety of biotechnology experiments from the simple to the more difficult. ... Read more