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MicroRNAs (miRNAs) are RNA molecules, conserved by evolution, that regulate gene expressions and their recent discovery is revolutionising both basic biomedical research and drug discovery. Expression levels of MiRNAs have been found to vary between tissues and with developmental stages and hence evaluation of the global expression of miRNAs potentially provides opportunities to identify regulatory points for many different biological processes. This wide-ranging reference work, written by leading experts from both academia and industry, will be an invaluable resource for all those wishing to use miRNA techniques in their own research, from graduate students, post-docs and researchers in academia to those working in R&D in biotechnology and pharmaceutical companies who need to understand this emerging technology. From the discovery of miRNAs and their functions to their detection and role in disease biology, this volume uniquely integrates the basic science with industry application towards drug validation, diagnostic and therapeutic development.

Forewords by:
Sidney Altman, Yale University, Winner of the Nobel Prize in Chemistry, 1989
and
Victor R. Ambros, Dartmouth Medical School, Co-discoverer of MicroRNAs ... Read more

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This volume will discuss all important aspects of RNase P structure and function in eukaryotic, prokaryotic, and viral systems. It will cover a broad range of subjects in RNA research, including: structural analysis by biochemical or biophysical means; mRNA structure, function and biogenesis; ribosome structure and function; translational control; and RNA catalysis. RNA and RNase is an interdisciplinary topic that represents molecular, evolutionary and structural biology, biochemistry, biomedical sciences, chemistry, genetics, and virology as they relate to questions of the structure and function of RNA and of ribonucleoprotein assemblies.

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Chapters: Roberta Bondar, Sidney Altman, Charles Philippe Leblond, Neil Brown, Félix D'herelle, Shiv Chopra, Shirley M. Tilghman, Charles E. Saunders, Daniel Pauly, Thomas Henry Manning, Peter L. Hurd, Peter Watts, Irwin Murray Brodo, Villy Christensen, Tony J. Pitcher, Stanford Blade, T. Ryan Gregory, John Murray, Mark Wainberg, Ray Hilborn, Louis Siminovitch, Brian Goodwin, Charles Frederick Hartt, Lorne Babiuk, Henry Friesen, Charles Leonard Huskins, Aled Edwards, Robert Haynes, Frank Grosveld, Anne Vallée, Richard Keith Downey, Edgar Archibald, Arthur Ham, Armand Frappier, Keith L. Moore, Paul D. N. Hebert, Harold Copp, Cheryl Arrowsmith, Fernand Seguin, Gord Miller, Alice Wilson, Charles J. Lumsden, Heather Deal, Olga Kukal, Brian S. Leander. Source: Wikipedia. Pages: 165. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Charles Philippe Leblond, CC, FRSC, FRS (February 5, 1910 April 10, 2007) was a pioneer of cell biology and stem cell research and a former Canadian professor of anatomy. Leblond is notable for developing autoradiography and his work showing how cells continuously renew themselves, regardless of age. In 1946, Leblond found that, when he poured liquid photographic emulsion on a histological section containing a radio element, the emulsion was eventually activated by the radio-element; and if thereafter routine photographic development and fixation were applied to the emulsion-covered section, black silver grains appeared in the emulsion wherever it overlay sites containing a radio-element. This liquid emulsion approach has been used to develop a new High Resolution Autoradiography procedure characterized by close contact between emulsion and section. Such close contact makes it possible to localize the radio-elements in the section at high resolution, so that radio-ele...More: http://booksllc.net/?id=2057953 ... Read more

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Chapters: Oswald Avery, James D. Watson, Francis Crick, Max Perutz, Rosalind Franklin, Sidney Altman, Bonnie Bassler, Susan Lindquist, List of Geneticists, Maurice Wilkins, François Jacob, Gerald Domingue, Maclyn Mccarty, Dorian Bevec, Gordon H. Sato, Douglas Prasher, Luca Turin, John Gofman, Jean-Pierre Lecocq, Ernesto Bustamante, Angelika Amon, Elizabeth Blackburn, Shirley M. Tilghman, John Kendrew, Joan A. Steitz, Paul M. Bingham, Jay Winsten, Richard I. Morimoto, Tillman Gerngross, Steven A. Benner, Seymour Benzer, William Astbury, Richard A. Houghten, Thomas Cremer, Leslie Barnett, Utpal Banerjee, Carol W. Greider, Emile Zuckerkandl, Charles Delisi, Richard Lathe, Stanley Michael Gartler, Elwood V. Jensen, Harvey Bialy, Thomas Silhavy, Alfred Mirsky, Axel Ullrich, Edwin Southern, Susumu Tonegawa, Ehud Gazit, Stephen G. Hall, Giulio Superti-Furga, Michael Wigler, Richard D. Wood, Kaj Ulrik Linderstrøm-Lang, Charles Brenner, George Streisinger, Lynn W. Enquist, Bruce Ames, Richard Anthony Jefferson, Martin Henry Dawson, Tom Maniatis, Graham Cairns-Smith, Noreen Murray, H. Michael Shepard, Israel Hanukoglu, Hans Neurath, Scott Woodward, Sol Spiegelman, Mortimer Louis Anson, Anita Roberts, Leonard Lerman, David A. Mcclellan, Leo Sachs, Jerry Adams, Frank Grosveld, Franklin Stahl, Wojciech Rychlik, Richard Henderson, Peter Walter, Cyrus Levinthal, John T. Lis, Matt Kaeberlein, Thomas Tuschl, John Kuriyan, Paul Chun, Nader Pourmand, Richard A. Jorgensen, John Tileston Edsall, William Mcginnis, Saba Valadkhan, Eva Nogales, Harvey Lodish, Mark Ptashne, Paul Schedl, Yoshiyuki Sakaki, Jack Myers, Stanley Fields, Charles Frederick Ehret, John Derek Smith, Alexander Spirin, Patrick J. Keeling, Roy John Britten, Vamsi Mootha, James C. Wang, Napoleone Ferrara, Nathaniel David, Pamela Silver, Paulo Sérgio Azevedo, Norman Simmons, J. Norman Davidson, Hans J. Müller-Eberhard. Source: Wikipedia. Pages: 474. Not illustrated. Free updates o...More: http://booksllc.net/?id=11461 ... Read more

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Chapters: Oswald Avery, William Lyon Mackenzie King, Marshall Mcluhan, Steven Pinker, Sidney Altman, William Osler, Ian Stevenson, Donald O. Hebb, Erving Goffman, Wade Davis, Peter Mclaren, David Bromige, Helen Fisher, Albert Bandura, Norma Cole, David H. Hubel, Cathleen Synge Morawetz, C. S. Holling, Henry Taube, Elaine Bernard, Merlin Donald, Ernest Burgess, Ghazi Falah, Elie Abel, Patricia Churchland, James Hillier, Charlotte Froese Fischer, Irving Kaplansky, Charles Frederick Hartt, Jacob Gould Schurman, Pierre Dansereau, Martin Henry Dawson, Rudolph A. Marcus, Roxana Moslehi, Donald B. Redford, Marc Shell, Albert Ross Hill, Louis Nirenberg, David Staines, Maud Menten, Renee Baillargeon, Ivan M. Niven, Brian A. Barsky, Lionel Tiger, Kenneth G. T. Webster, Homer Thompson, Peter J. Brand, Dan Milisavljevic, Robert Methven Petrie, Daniel Murray. Source: Wikipedia. Pages: 256. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Herbert Marshall McLuhan, CC (July 21, 1911 December 31, 1980) was a Canadian educator, philosopher, and scholara professor of English literature, a literary critic, a rhetorician, and a communication theorist. McLuhan's work is viewed as one of the cornerstones of the study of media theory. McLuhan is known for the expressions "the medium is the message" and "global village". McLuhan was a fixture in media discourse from the late 1960s to his death and he continues to be an influential and controversial figure. More than ten years after his death he was named the "patron saint" of Wired magazine. McLuhan was born in Edmonton, Alberta, to Methodist parents Elsie Naomi (née Hall) and Herbert Ernest McLuhan. His brother, Maurice, was born two years later. "Marshall" was a family name: his maternal grandmother's surname. Both of his parents were born in Canada. His mother w...More: http://booksllc.net/?id=19548 ... Read more

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Chapters: Steve Wozniak, William Luther Pierce, W. Edwards Deming, Sidney Altman, David Zindell, Loren Acton, Kalpana Chawla, Joe Rice, Tsakhiagiin Elbegdorj, Rob Briley, Ellen Johnson Sirleaf, Ron Larson, Karen Middleton, Harold Montgomery, Jack Williamson, John Morse, Tyler Hamilton, Alexandra Stevenson, John A. Eddy, Bruce Dehning, Spencer Swalm, Abhinav Bindra, Vine Deloria, Jr., Elisabeth Kübler-Ross, Chris Myers, Dave Grusin, Ryan Bradley, Frank W. Mayborn, Vance D. Brand, Ellison Onizuka, Alan Ford, Dean Reed, James S. Voss, Spider Sabich, Richard S. Fuld, Jr., Edward Nottingham, Kenneth R. Miller, Joe Flanigan, Rick Alden, John Fante, Wiley Blount Rutledge, Hansford T. Johnson, Ronald M. Sega, Kabiné Komara, Edward Ellsberg, William T. Kane, Roger A. Pielke, Jr., Big Head Todd and the Monsters, Marshall Bell, Anne Gorsuch Burford, Richard A. Sossi, Billy Kidd, William J. Begert, Paul Goldberg, Alex Gurney, Sue Schafer, Christine Arguello, Jim Green, Dean T. Prosser, Derek Rundell, Kirby Wright, Lynn Schofield Clark, William J. Leveque, William R. Corliss, Stuart Roosa, Matthew Emmons, George Mackinnon, Tera Moody, Luís Alberto Urrea, Clinton Jencks, John M. Lounge, Mack Barham, Jonathan Holden, Jennifer Veiga, Richard T. Johnson, Mark Stephen Meadows, Jimmie Heuga, Wayne Higby, Sanford N. Mcdonnell, Purnomo Yusgiantoro, David Messerschmitt, Joseph Nation, Sheridan Titman, Steve Ells, A. Reynolds Morse ... Read more

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Chapters: Frederick Banting, Saul Bellow, William Vickrey, John James Richard Macleod, Sidney Altman, Myron Scholes, Robert Mundell, Lester B. Pearson, Charles Brenton Huggins, Gerhard Herzberg, Willard Boyle, David H. Hubel, Henry Taube, William Giauque, Richard E. Taylor, Michael Smith, John Charles Polanyi, Bertram Brockhouse, Rudolph A. Marcus. Source: Wikipedia. Pages: 107. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Lester Bowles "Mike" Pearson, PC, OM, CC, OBE (23 April 1897 27 December 1972) was a Canadian professor, historian, civil servant, statesman, diplomat, and politician, who won the Nobel Peace Prize in 1957 for organizing the United Nations Emergency Force to resolve the Suez Canal Crisis. He was the 14th Prime Minister of Canada from 22 April 1963, until 20 April 1968, as the head of two back-to-back minority governments following elections in 1963 and 1965. During his time as Prime Minister, Pearson's minority government introduced universal health care, student loans, the Canada Pension Plan, the Order of Canada, and the current Canadian flag. During his tenure, Prime Minister Pearson also convened the Royal Commission on Bilingualism and Biculturalism. With these accomplishments, together with his groundbreaking work at the United Nations and in international diplomacy, Pearson is generally considered among the most influential Canadians of the 20th century. Pearson was born in Newtonbrook, Toronto, the son of Edwin Arthur Pearson, a Methodist (later United Church of Canada) minister and Anne Sarah Bowles. He graduated from Hamilton Collegiate Institute in Hamilton, Ontario in 1913 at the age of 16. Later that same year, he entered Victoria College at the University of Toronto, where he lived in residence in Gate House and shared a room with his brother Duke. Whi...More: http://booksllc.net/?id=19280671 ... Read more

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High Quality Content by WIKIPEDIA articles! Ribonuclease P (RNase P) is a type of Ribonucleasewhich cleaves RNA. RNase P is unique from other RNasesin that it is a ribozyme ? a ribonucleic acidthat acts as a catalyst in the same way that a protein based enzyme would. Its function is to cleave off an extra, or precursor, sequence of RNA on tRNA molecules [1]. Further RNase P is one of two known multiple turnover ribozymes in nature (the other being the ribosome), the discovery of which earned Sidney Altman and Thomas Cech the Nobel Prize in Chemistry in 1989. In fact, Sidney Altman discovered the existence of precursor tRNA with flanking sequences and was the first to characterize RNase P and its activity in processing of the 5' leader sequence of precursor tRNA back in the 70's. ... Read more