Geometry.Net - Science: Endocrine Disruptors

Health Effects From Endocrine Disruptors
EMCOM is a website about endocrine disruptors and environmental estrogensand their effects on human health. The prefered site for
http://www.emcom.ca/
In-Vitro Recombinant Yeast Assay And In-vivo Uterotrophic Assay To Screen For Oe
endocrine disruptors.
http://www.safepharm.co.uk/Services/Toxicology/endocrine-disruptors.html

Extractions: The Department of Ecotoxicology has validated a sensitive and specific in vitro screening test for oestrogenic chemicals using a recombinant yeast assay. This assay allows for the generation of reproducible empirical biological data to be obtained in a cost-and-time-effective manner. A simple colour change from yellow to red, measured by a spectrophotometer, indicated the presence of an oestrogenic chemical. The intensity of the colour change is directly related to the oestrogenic activity. This assay has been shown to be suitable for both neat chemicals and environmental samples and complements the in vivo mammalian methods also available at SPL . A similar assay for androgenic activity has also been validated. The Department now offers a full range of oestrogen, androgen, anti-oestrogen and anti-androgen screens. Widespread concern exists over environmental contaminants that can mimic the biological activities of the female hormone, oestrogen. A wide range of chemicals has been shown to be weakly oestrogenic. These include both natural chemicals, such as phytoestrogens and mycoestrogens, as well as synthetic chemicals such as pesticides, polychlorinated biphenols, plasticisizers and the degradation products of surfactants. The regulatory response to these concerns has been spearheaded by the US Environmental Protection Agency, which is mandated to screen some 15000 chemicals for endocrine disrupting effects.
Endocrine Disruptors, Estrogens
Alphabetical Index of Health Topics endocrine disruptors, Estrogens Question Whatis all the talk I'm hearing about endocrine disruptors in the environment? .
http://www.niehs.nih.gov/external/faq/endisrp.htm

Extractions: Endocrine Disruptors, Estrogens Question: "What is all the talk I'm hearing about endocrine disruptors in the environment?" Answer: Disruptions in the endocrine system and hormone levels it produces can lead to cancers and irregularities in the reproductive system. Some scientists propose that hormones can induce cancers by directly altering genetic material (DNA) or can induce cancers indirectly through cellular activities. Many researchers think that hormone imbalance can lead to increased rates of cancers and reduced fertility. Scientists are also developing genetic biomarkers for early detection of cancers, as well as new therapies and prevention. Click here for full story in Environmental Health Perspectives - the journal of the National Institute of Environmental Health Sciences Back to Alphabetical Index of Health Topics
CfT And Endocrine Disruptors
CfT and endocrine disruptors. With experts in endocrine toxicology CfT iswellplaced to take a leading role in projects in this growing area.
http://www.centrefortoxicology.com/activities/endocrine/

Extractions: Endocrine disruptors, Risk assesssment, Biomarkers, Food Safety, Training and Education What's new, meetings and courses, calls for interest About the Centre for Toxicology CfT and Endocrine Disruptors With experts in endocrine toxicology CfT is well-placed to take a leading role in projects in this growing area. Particularly of interest are non-oestrogen endocrine targets.
EPA: ORD: NCER: Research Opportunities: Endocrine Disruptors
4. endocrine disruptors. Additional information regarding research needs on endocrinedisruptors may be found in the following references Ankley, GT, et al.
http://es.epa.gov/ncer/rfa/archive/grants/97/endocrine.html

Extractions: Advanced Search Closed - for reference purposes only Evidence has been accumulating that humans and domestic and wild species have suffered adverse health consequences resulting from exposure to environmental chemicals that interact with the endocrine system. These pollutants are collectively referred to as "endocrine disruptors," a term broadly defined as "an exogenous agent that interferes with the production, release, transport, metabolism, binding, action, or elimination of natural hormones in the body responsible for the maintenance of homeostasis and the regulation of developmental processes." In response to growing public health concerns related to chemicals in the environment which have the potential to act as endocrine disruptors, the Office of Research and Development of the EPA included Endocrine Disruptors as a high priority research issue in the ORD Strategic Plan and has developed an Endocrine Disruptors Research Plan. The plan identifies the need for three broad categories of research: biological-effects studies, exposure studies, and studies on the linkage of exposure and effects. Grant applications are sought in each category. The focus of the research may range from studies on wildlife populations and laboratory organisms, to humans, in both laboratory and field settings.
1999 Progress Report: Endocrine Disruptors: Effect On The Thyroid
1999 Progress Report endocrine disruptors Effect on the Thyroid.EPA Grant Number R826297 Progress Report endocrine disruptors
http://es.epa.gov/ncer/progress/grants/97/endocrine/klaassen99.html

Extractions: Objective(s) of the Research Project: The ultimate goal of this project is to assess the significance of endocrine disruptors that increase thyroxine (T ) glucuronidation on thyroid carcinogenesis because many endocrine disruptors are suspected to be thyroid tumor promoters. The mechanism by which endocrine disruptors promote thyroid tumors has been proposed to result from alterations in the thyroid-pituitary-hypothalamus axis. Endocrine disruptors alter the thyroid-pituitary-hypothalamus axis by increasing T glucuronidation and elimination, which reduces serum T . As a compensatory feedback mechanism, thyroid stimulating hormone (TSH) will be released from the pituitary, which will stimulate the thyroid, and result in thyroid follicular cell proliferation and ultimately neoplasia. However, the preliminary studies suggest that a number of endocrine disruptors interfere with the normal hypothalamus-pituitary-thyroid axis because these endocrine disruptors do not increase serum TSH. Therefore, the central hypothesis of this application is that endocrine disruptors that increase T4 glucuronidation are thyroid tumor promoters only when they increase serum TSH.
Endocrine Disruptors
We are sending you background information about a serious environmental and publichealth problemendocrine disruptors which will be widely discussed in the
http://www.gascape.org/index /Endocrine Disruptors.html

Extractions: Dear Friends, W e are sending you background information about a serious environmental and public health problemendocrine disruptors which will be widely discussed in the media during the coming days. Because of your important role in public health, the environment and sustainable agriculture, we thought you might want to be briefed prior to the media attention which will be devoted to this problem. The ensuing debate will probably reprise the contentiousness of the release of "Silent Spring" since it will threaten industrial production of many chemicals currently in wide spread use. The following information outlines the problem, defines 'endocrine' and 'hormone', explains endocrine disruption processes and sources of contamination. Finally, it offers some options for action. Please forward this on to anyone you think might be interested in this issue. Sincerely, Carolyn Raffensperger Peter deFur Endocrine Disruptors The Problem Scientists are certain that a number of synthetic chemicals act like hormones (especially estrogens) and interact with hormone systems. Scientists have known for years that some of these chemicals are able to affect animals in subtle ways, as Rachel Carson so eloquently described. Scientists also agree that the magnitude of the problem (including human exposure) is uncertain. The puzzle is still being pieced together. Studies over several years and recent reports of those studies in both the scientific literature and popular media have demonstrated serious wildlife and human health problems caused by endocrine disruptor chemicals. A new book on the subject due out in March, outlines the detective story and the consequences of these chemicals in biological systems. The book, "Our Stolen Future", raises important issues of science, regulation and policy concerning the effects of pesticides, industrial chemicals and other toxic substances on human health and the environment.
Evaluating The Effects Of Endocrine Disruptors On Endocrine Function During Deve
Evaluating the Effects of endocrine disruptors on Endocrine Functionduring Development. Environmental Health Perspectives
http://ehpnet1.niehs.nih.gov/docs/1999/suppl-4/613-618bigsby/abstract.html

Extractions: Environmental Health Perspectives Volume 107, Supplement 4, August 1999 Citation in PubMed Related Articles Robert Bigsby, Robert E. Chapin, George P. Daston, Barbara J. Davis, Jack Gorski, L. Earl Gray, Kembra L. Howdeshell, R. Thomas Zoeller, and Frederick S. vom Saal Indiana University School of Medicine, Indianapolis, Indiana USA; Key words: androgen, development, embryo, endocrine disruptors, estrogens, fetus, thyroid. Environ Health Perspect 107(suppl 4):613-618 (1999). http://ehpnet1.niehs.nih.gov/docs/1999/suppl-4/613-618bigsby/abstract.html This report was developed at the Workshop on Characterizing the Effects of Endocrine Disruptors on Human Health at Environmental Exposure Levels held 11-13 May 1998 in Raleigh, North Carolina. Address correspondence to F.S. vom Saal,114 Lefevre Hall, Division of Biological Sciences, University of Missouri, Columbia, MO 65211. Telephone: (573) 882-4367. Fax: (573) 884-5020. E-mail:
Introduction--Workshop On Characterizing The Effects Of Endocrine Disruptors On
IntroductionWorkshop on Characterizing the Effects of endocrine disruptorson Human Health at Environmental Exposure Levels.
http://ehpnet1.niehs.nih.gov/docs/1999/suppl-4/603-604melnick/melnickintro.html

Extractions: Environmental Health Perspectives Volume 107, Supplement 4, August 1999 Citation in PubMed Related Articles Ronald L. Melnick National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina USA Reports in the scientific literature and in the media have raised concerns that certain persistent environmental chemicals may be producing adverse effects in wildlife and in humans by interfering with the endocrine system. Some of the effects include reproductive and developmental abnormalities, increases in certain hormone-related cancers (breast, prostate, testis), and declines in wildlife populations. The term endocrine disruptors is used to describe exogenous agents that act by mimicking or antagonizing natural hormones in the body that are responsible for maintaining homeostasis and controlling normal development. Because hormone receptor systems are similar in humans and animals, effects observed in wildlife species raise concern of potential human health effects. Evaluating potential low-dose effects of environmental estrogens was identified as a major research priority at the 1997 NIEHS conference "Estrogens in the Environment." The format of the present workshop, as well as the specific issues that needed to be addressed, was conceived by an organizing committee composed of K. Korach, C. Portier, M. Shelby, and R. Melnick (chair; NIEHS); R. Kavlock (U.S. EPA); P. Foster (Chemical Industry Institute of Toxicology); D. Sheehan and B. Delclos (FDA/NCTR); F. vom Saal (University of Missouri); and R. Miller (Dow Chemical Co.). To address the workshop objectives, the organizing committee identified six breakout group topics:
Endocrine Disruptors And Carcinogenic Risk Assessment
endocrine disruptors and Carcinogenic Risk Assessment. Volume 340NATO Science Series Life and Behavioural Sciences Edited by L
http://www.iospress.nl/site/html/boek1635768026.html

Extractions: The book is devoted to the study of the endocrine-related effects on human health with special reference to carcinogenesis, and to the assessment of carcinogenic risk. After providing basic information at the general, cellular and molecular levels, the contents focus on the paradigm of Biologically Based Risk Assessment, as developed form Physiologically-Based Toxicokinetic Models. The analysis of this material is proposed as the novel parameters for developing Biologically Based Models of Carcinogenesis, considered to be more relevant to risk assessment than traditional approaches. This data appears unique in an important and rapidly developing field.
Endocrine Disruptors Resources
Web Sources For Consumer Information on endocrine disruptors. EndocrineDisruptors Research Initiative. An inventory of federal government
http://library.niehs.nih.gov/consumer/endocrine.htm
Infertility Books.com - Endocrine Disruptors: Effects On Male And Female Reprodu
endocrine disruptors Effects on Male and Female Reproductive Systems. 3Ovotoxic Environmental Chemicals Indirect endocrine disruptors 57.
http://www.infertilitybooks.com/professionals/titles/endocrine_disruptors.html

Extractions: Pub. Date: January 1999 An examination of the hazards environmental toxicants pose to reproductive function. Endocrine Disruptors: Effects on Male and Female Reproductive Systems examines the epidemiology and etiology of environmental toxicants/hormone imposters, many of which act as reproductive toxicants that cause fertility problems and carcinogenic hazards. Thus far, over fifty such hormone imposters/persistent organic pollutants (POPs) have been identified, the most common of which are organochlorines (DDT, PCBs) and dioxins. This book discusses the hazardous effects of endocrine disruptors on gonads, fertility, and sexual and reproductive function, and health hazards leading to the alarming decline in global fertility and rising incidences of breast and prostate cancer. Endocrine Disruptors: Effects on Male and Female Reproductive Systems examines the epidemiology and etiology of environmental toxicants, or "hormone imposters," many of which act as reproductive toxicants that cause fertility problems. This book addresses alarming issues such as declining global fertility; rising incidences of breast and prostate cancer; and the wide variety of toxic effects that the synthetic chemicals, termed endocrine disruptors, exert on the gonads, fertility, and sexual and reproductive function.
Greencape
endocrine disruptors endocrine disruptors For information about endocrinedisruptors, go to the following links World Wildlife
http://www.greencape.org/endocrine.html

Extractions: Endocrine disruptors are synthetic chemicals that mimic or otherwise interfere with naturally produced hormones that control how an organism develops and functions. Wildlife and humans are constantly exposed to these pervasive and often persistent chemicals. They have been implicated in the rising levels of breast, testicular and prostate cancer. They cause reproducuctive abnormalities and infertility. There is strong evidence that they cause behavior and learning problems in children. For information about endocrine disruptors, go to the following links: World Wildlife Fund: Endocrine Disruptors: A superb introduction to the whole problem of endocrine disruptors, how they are related to Persistent Organic Pollutants (POP's) and the science that supports the growing concern over these chemicals. Introduction to Hormone Disrupting Chemicals: This site was created by Dr. A. Michael Warhurst, an Environmental chemist whop works for Friends of the Earth in London. Clear and Concise informatin, presented in an easy to understand way. EPA Endocrine Disruptor Page: This web site provides information aboout the endocrine system and why certain chemicals can affect it, how the EPA Endocrine Disruptor Screening Program was developed, and the current status of EPA's implementation activities.
Endocrine Disruptors - Interview With Dr Colborn
Our Stolen Future. The dangers of endocrine disruptors an interviewwith Dr Theo Colborn. What are endocrine disruptors? TOXICS poisons.
http://www2.gol.com/users/bobkeim/pesticides/colborn.html

Extractions: By accident! I was asked to be a scientist on a team of Americans and Canadians who were investigating the environment of the area around Michigan, on the Great Lakes. It was known that the area was heavily polluted, but there was little information about the health of the people who lived there. "I was amazed by what I found."
Endocrine Disruptors In Drinking Water
endocrine disruptors in drinking water are being found all over the country. Manyhealth problems, including cancer, are attributed to endocrine disruptors.
http://www.purewater4u.com/freeinfo/endocrine.shtml

Extractions: Endocrine Disruptors In Drinking Water Evidence is growing that a serious health link exists between chemicals that mimic the hormone estrogen and damage to the human reproductive system. Known as Endocrine Disruptors, these chemicals are widely distributed in the environment. To understand how endocrine disruptors function, let's first take a look at the endocrine system itself. The endocrine system is a complex set of bodily organs and tissues whose actions are coordinated by chemical messingers called hormones. These hormones control reproduction, growth, development and behavior. If these chemical "messages" are disrupted by chemicals that mimic the hormones, then the systems receiving the messages are going to be damaged. The range of problems that may be caused by hormone disruption is large: cancer, birth defects, stubted growth, reproductive failure, diminished sperm count, endometriosis, tubal pregnancy, damage to the immune system, loss of muscle tone, weakened reflexes, imparement of short-term memory, decreased ability to pay attention, lower I.Q. and violent behavior. Endocrine disruptors can get into water supplies in various ways. Since many endocrine disruptors are herbicides and pesticides, agricultural runoff can carry these chemicals into water supplies. Some are products of industrilization and may get into water supplies through various means, such as leaking storage tanks, accidental spills or illegal dumping.
Scientists Lose Sleep Over Endocrine Disruptors - 10/28/2000 - ENN.com
Scientists know that endocrine disruptors enter the environment in avariety of ways. Scientists lose sleep over endocrine disruptors
http://www.enn.com/news/enn-stories/2000/10/10282000/endodisrupt_39491.asp

Extractions: Site Index: Home News ENN Earthnews Affiliates News In-Depth Topics Interact Online Quizzes Postcards Marketplace Advanced Search Advertise Join ENN e-mail Subscription Take our Survey Affiliate Tech Center Post Press Release Help About ENN Site Map Scientists lose sleep over endocrine disruptors Saturday, October 28, 2000 By Lucy Chubb Endocrine disruptors released into the environment include industrial effluent from sources such as paper mills. This mill is set on the Canadian side of St. Mary's River near Lake Huron. In the early 1980s, British scientists studying aquatic life in the Thames River system discovered several fish with a confusing gender issue. Some fish that were supposed to be male according to their genetic code had, in fact, developed as females. This hermaphroditic condition was traced back to environmental contaminants now known as endocrine disruptors Scientists are aware that endocrine disruptors enter the environment through a variety of means: household cleansers, plastic products, pesticides, agricultural sites and industrial effluent. The United States and certain countries in Europe are working on regulations to end the release of these harmful chemicals. But dedicated facilities are not in place for determining exactly which ones, where and in what concentration these chemicals are present.
Wales | Endocrine Disruptors | Celtic Confederation
back to Wales home endocrine disruptors. The occurrence of endocrinedisrupting chemicals (EDCs) in the environment, and their potential
http://www.celticconfederation.com/wales/chemicals.shtml

Extractions: Endocrine Disruptors The occurrence of endocrine disrupting chemicals (EDCs) in the environment, and their potential effects on human and animal health, is a very important emerging issue with major ecological implications. Endocrine glands secrete hormones that control important aspects of bodily growth and function. A number of chemicals can disrupt various functions of the endocrine system. EDCs can bind with the hormone receptor and either mimic a hormone, triggering an identical response, or block a hormone from triggering the response. EDCs also can interfere with hormonal activity without bonding to the receptor. EDCs can harm reproductive health, and are suspected of causing hormonally-sensitive carcinoma (i.e.. breast, cervical, prostate and testicular cancer). Known and suspected EDCs include natural and synthetic estrogens, phytoestrogens that occur naturally in some vegetables, and manufactured chemicals including polychlorinated biphenyls (PCBs), dioxins, plasticizers, detergents, tributyltin (TBT) and organochlorine insecticides such as DDT and Lindane. Prenatal exposure to environmental xenoestrogens has been suggested as one possible cause of low sperm count in young men in Great Brittian. The
Scotland | Endocrine Disruptors | Celtic Confederation
back to Scotland home endocrine disruptors Chemicals. The occurrenceof endocrine disrupting chemicals (EDCs) in the environment, and
http://www.celticconfederation.com/scotland/chemicals.shtml

Extractions: Endocrine Disruptors Chemicals The occurrence of endocrine disrupting chemicals (EDCs) in the environment, and their potential effects on human and animal health, is a very important emerging issue with major ecological implications. Endocrine glands secrete hormones that control important aspects of bodily growth and function. A number of environmental chemicals can disrupt various functions of the endocrine system. EDCs can bind with the hormone receptor and either mimic a hormone, triggering an identical response, or block a hormone from triggering the response. EDCs can also interfere with hormonal activity without bonding to the receptor. EDCs can harm the reproductive health of males, and are suspected of causing hormonally-sensitive carcinoma (i.e. breast, cervical, prostate and testicular cancer). Known and suspected EDCs include natural and synthetic estrogens, phytoestrogens that occur naturally in some vegetables, and manufactured chemicals including polychlorinated biphenyls (PCBs), dioxins, plasticizers, detergents, and organochlorine insecticides such as DDT. Prenatal exposure to environmental xenoestrogens has been suggested as one possible cause of low sperm count in young Scottish men. The
Integrated Complex Pathways Of Endocrine Disruptors In Zebrafish -- Mark S. Gree
Integrated Complex Pathways of endocrine disruptors in Zebrafish Mark S. Greeley.ESD Home, Integrated Complex Pathways of endocrine disruptors in Zebrafish.
http://www.esd.ornl.gov/research/greeley_highlight.html
ENVIRONMENTAL ESTROGENS AND OTHER ENDOCRINE DISRUPTORS
ENVIRONMENTAL ESTROGENS AND OTHER endocrine disruptors MCV/VCU, Fall2001. CELL SIGNALING Raphael J. Witorsch, Ph.D. witorsch@hsc.vcu.edu.
http://www.witorsch.com/Ray/Raypage3.htm

Extractions: witorsch@hsc.vcu.edu My major scholarly interest throughout my academic career has been in the area of hormone research. In addition to publishing widely in this area, I have taught endocrinology to medical students, graduate students, and other health professionals for over 30 years. In view of my research and teaching interest and my activities as a toxicology consultant, it should come as no surprise that I would develop a particular interest in the controversial area of environmental estrogens and other endocrine disruptors. My interest in this area stimulated the development of a curriculum on this particular issue for a graduate course we offer at MCV/VCU. The course is given every two years. What follows is the list of topics discussed and a selected reading list from our last course offering. PHIS 617 - 2001 - Endocrine Disruption: Mechanistic Considerations - Professor R. J. Witorsch

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

61-80 of 104 Back | 1 | 2 | 3 | 4 | 5 | 6 | Next 20