81. Creutzfeldt-Jakob Syndrome The Human BSE Foundation (HBSEF) provides support and advice for relatives, friendsand carers of victims of Variant Creutzfeldt Jacob disease (vCJD). http://omni.ac.uk/browse/mesh/detail/C0022336L0022336.html

Creutzfeldt-Jakob Syndrome [up] Creutzfeldt-Jakob Syndrome / etiology Creutzfeldt-Jakob Syndrome / transmission Related topics: broader Dementia Prion Diseases other AIDS Dementia Complex Alzheimer Disease Dementia, Vascular Encephalopathy, Bovine Spongiform ... BMJ BSE-CJD home page This homepage provided by the British Medical Journal gathers together Government statements and BMJ extracts on Bovine Spongiform Encephalopathy (BSE) and Creutzfeldt-Jakob Disease (CJD), brain diseases affecting cattle and humans respectively, covering the BSE debate since 1988. Creutzfeldt-Jakob Syndrome Encephalopathy, Bovine Spongiform BSE inquiry The BSE Inquiry was set up in December 1997 by the government, which aims to investigate the emergence and identification of Bovine Spongiform Encephalopathy (BSE) and the new variant CJD (Creutzfeldt-Jakob disease) in the UK. Their homepage here provides information from this inquiry, including the background to the story, draft full-text factual accounts (in HTML or PDF formats), press releases, witness statements and transcripts. Also provided is a glossary, timetables, and a list of people involved with the Inquiry. Creutzfeldt-Jakob Syndrome Encephalopathy, Bovine Spongiform

82. Nature Medicine fails to indicate that in the late 1960s, in the wake of the dramatic demonstrationof the transmissibility of kuru and Creutzfeldt Jacob disease (a rare but http://www.nature.com/nm/wilma/v3n8.870469305.html

book review AUGUST 1997 Table of Contents AUGUST 1997 Volume 3 Number 8 p925 Deadly Feasts: Tracking the Secrets of a Terrifying New PlagueBy Richard Rhodes By Richard Rhodes Reviewed by Neal Nathanson This book provides a layman's account of the diseases known collectively as transmissible spongiform encephalopathies (TSEs), which are caused by a novel group of agents often referred to as prions. The story is developed along historical lines, beginning in the 1950s with investigations by Carleton Gajdusek of kuru (an epidemic neurological disease that occurred in the stone age peoples living in the highlands of eastern New Guinea), bringing in scrapie of sheep (the prototype of the TSEs), and ending with the epidemic of bovine spongiform encephalopathy (BSE) that began in the United Kingdom in the 1980s and is predicted to end over the next five years. The author has done extensive bibliographic research and conducted numerous interviews with many of the scientists who have worked in this field, with the notable exception of Stanley Prusiner (who does not give interviews) and several of his outstanding collaborators. Judged as a chronicle for a lay audience, this is a well wrought presentation that captures the readers' interest at the outset and builds the story piece by piece to form a coherent narrative. It informs painlessly while maintaining the tension of a good tale to the very end. This book has been the subject of several recent reviews

83. Variant Creutzfeldt-Jakob Disease (vCJD) Surveillance prediction about the future number of vCJD cases. Variant CreutzfeldtJacobdisease (vCJD) November 2002 (revised). WHO Fact Sheet No. http://www.who.dk/foodsafety/Otherissues/20020417_12

var strWHOEmblem = "/images/WHOimages/WHOEmblems/" + strEmblem ; document.write(""); document.write(" " + strWHO + " " + strEURO + ""); English Deutsch Home Country Information Health Topics ... Transmissible spongiform encephalopathy (TSE) Variant Creutzfeldt-Jakob Disease (vCJD) surveillance Variant Creutzfeldt-Jakob disease (vCJD) is a rare and fatal human neurodegenerative condition. Like Creutzfeldt-Jakob disease (CJD), vCJD is classified as a transmissible spongiform encephalopathy (TSE) because of characteristic spongy degeneration of the brain and the tranmissability of the disease. First described in March 1996, vCJD is strongly linked with exposure to the BSE agent. From October 1996 to early November 2000, 85 cases of vCJD have been reported in the United Kingdom, 3 in France and 1 in Ireland. Insufficient information is available at present to make any wellfounded prediction about the future number of vCJD cases. Variant Creutzfeldt-Jacob disease (vCJD) November 2002 (revised). WHO Fact Sheet No. 180 United Kingdom CJD Surveillance Unit Link to Variant Creutzfeldt-Jakob Disease (vCJD) surveillance at headquarters Joint WHO/FAO/OIE Technical Consultation on BSE: Public Health, Animal Health and Trade

84. CJDVoice.org    Support  - Education - News Updates - Chat Enter Here. http://members.aol.com/larmstr853/cjdvoice/cjdvoice.htm

Enter Here Enter Here

85. Links To Information About HHV-6 Wisconsin Viral Research Group, Ltd. Links to Additional Information. http://www.wisconsinlab.com/links.htm

Wisconsin Viral Research Group, Ltd. Links to Additional Information Home CWD HHV-6 The Lab ... Site Map Web Links Chronic Wasting Disease Milwaukee Journal Sentinel's excellent series of articles on CWD Website providing an excellent summary of current news articles concerning CWD Recent review article concerning chronic wasting disease in North American deer and elk Recent review article concerning bovine spongiform encephalopathy and variant Creutzfeldt-Jacob disease ... Recent review article comparing sporadic and variant Creutzfeldt-Jacob disease Miscellaneous Links All the Virology on the WWW - Dr David Sander's index site of virology information, images and tutorials. MS Related Links MedSupport FSF International - 24-hour Multiple Sclerosis Support National Institutes of Health Article - HHV-6 and Multiple Sclerosis National Multiple Sclerosis Society International Multiple Sclerosis Support Foundation Multiple Sclerosis Association of America The World of Multiple Sclerosis CFS Related Links The National CFIDS Foundation The CFIDS/ME Information Page The CFIDS Association of America American Association for Chronic Fatigue Syndrome ... CFS and FM Good Doctor List

86. Death Spurs CJD Riddle (4th October 1997) The WA woman suffering symptoms consistent with a new strain of CreutzfeldtJacobdisease has died in Royal Perth Hospital. RPH http://www.wantree.com.au/~rabbit/cjd.htm

Death spurs CJD riddle By Amanda Bower From: The West Australian , 4th October 1997 The WA woman suffering symptoms consistent with a new strain of Creutzfeldt-Jacob disease has died in Royal Perth Hospital. RPH confirmed that the woman, in her early 20's, died early yesterday, most likely from a complication of her immobility such as pneumonia or blood clots. She had been seriously ill for more than a month. Neurologist Graeme Hankey said it would take some weeks to establish whether the woman had, in fact, suffered from Creutzfeldt-Jakob disease, or CJD. A diagnosis of the extremely rare disease is only possible from an autopsy. The woman's illness confused experts at the hospital because her symptoms were consistent with two strains of CJD. The first strain affects one in a million people. Most victims are elderly and apart from about 10 per cent of hereditary cases, are randomly struck down. But the second strain, identified last year in Britain and known as nvCJD, has been linked to mad cow disease, or bovine spongiform encephalopathy. Scientists in London and Edinburgh claimed this week they had new evidence that nvCJD was the equivalent of mad cow disease and was almost certainly contracted by eating contaminated beef. Despite the scientists' findings, there is still considerable scientific debate about the link, and how it was possible to be "infected" with a non-infectious disease.

87. FoodlineWeb Is A Collection Of Food Information Databases From Leatherhead Food Earlier this month fears concerning the extent of new variant Creutzfeldt JacobDisease (vCJD) infection amongst the population were reignited when Stanley http://www.foodlineweb.co.uk/FoodWeb/newsletter/dec02/editorial.asp

FoodlineWeb Newsletter December 2002 BSE Update Spongiform Encephalopathies Analytical Techniques History of BSE ... The Future? Earlier this month fears concerning the extent of new variant Creutzfeldt Jacob Disease (vCJD) infection amongst the population were reignited when Stanley Prusiner suggested that all Britons should be tested for this form of the disease, under the belief that 1,000s of infected sheep and cattle may be entering the food chain (1, 2). The announcement follows new findings from Prusiner (who received the Nobel Prize for Medicine in 1997, after discovering that prions were the infectious agents responsible for spongiform encephalopathies such as CJD and colleagues from the University of California, San Francisco, who have developed the Conformation Dependent Immunoassay, an new test for the detection of abnormal prion proteins in tissue. Using this new test (see box ), the team was able to determine that mice infected with scrapie had unexpectedly high concentrations of abnormal prion particles in their muscle, with especially high concentrations in their hind legs. These findings have cast new doubt over the safety of cattle and sheep in the food chain. Where previously it was thought that only the nervous tissue of animals (such as the spinal cord and the brain) were capable of harbouring and transmitting these abnormal proteins, this new research suggests that they could also be present in the muscle of animals. Although these results have been found in mouse models only, it does prompt speculation that this could also be extended towards cuts of meat, such as beef and lamb, which contain a high proportion of muscle tissue. Additionally, although the levels of infection found in the tests were around one hundred fold less than those found in neural tissue, the results are still thought to be significant.

88. Literaturverzeichnis AlSarraj S, Ironside JW, Lantos PL, Collinge J. Investigation of variant Creutzfeldt-Jacobdisease and other human prion diseases with tonsil biopsy samples. http://www.schattauer.de/zs/medwelt/2001/6/pdf/bse_literatur.htm

A. Windhagen. Bovine Spongiforme Enzephalopathie (BSE): Hysterie oder Wahnsinn? Med Welt 2001; 52: 174-9. Literatur Aguzzi A. Spongiform encephalopathies: between cows and monkeys. Nature 1996; 381: 734-5. Aguzzi A, Brandner S. Shrinking prions: new folds to old questions. Nat Med 1999; 5: 486-7. Aguzzi A, Brandner S, Sure U, Rüedi D, Isenmann S. Transgenic and knock-out mice: models of neurodegenerative diseases. Brain Pathol 1994; 4: 3-20. Aguzzi A, Collinge J. Post-exposure prophylaxis after accidental prion inoculation. Lancet 1997; 350: 1519-20. Aguzzi A, Weissmann C. Prion research: the next frontiers. Nature 1997; 389: 795-8. Anderson RM, Donnelly CA, Ferguson NM, Woolhouse ME, Watt CJ, Udy HJ, MaWhinney S, Dunstan SP, Southwood TR, Wilesmith JW, Ryan JB, Hoinville LJ, Hillerton JE, Austin AR, Wells GA. Transmission dynamics and epidemiology of BSE in British cattle. Nature 1996; 382: 779-88. Brandner S, Raeber A, Sailer A, Blattler T, Fischer M, Weissmann C, Aguzzi A. Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system. Proc Natl Acad Sci USA 1996; 93: 13148-51. Brown P, Cervenakova L, McShane LM, Barber P, Rubenstein R, Drohan WN. Further studies of blood infectivity in an experimental model of transmissible spongiform encephalopathy, with an explanation of why blood components do not transmit Creutzfeldt-Jakob disease in humans. Transfusion 1999; 39: 1169-78.

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