Product Description
According to the Institute of Medicine (IOM) and U.S. Food and Drug Administration (FDA), "developing new scientific approaches to detecting, understanding, predicting, and preventing adverse events" was a critical path to the future of drug safety. This book brings together a collection of state-of-the-art chapters, written by experts in the drug safety field. It provides information on the present knowledge of drug side effects and their mitigation strategy during drug discovery, gives guidance for risk assessment, and promotes evidence-based toxicology. Each specific area of toxicology relevant for drug discovery is discussed in detail, including theory, experimental approaches, and data interpretation supported by comprehensive up-to-date references. Many chapters provide fascinating case studies, which are of general interest for those who have basic science training and are interested in how chemicals interact with the human body. ... Read more

Product Description
The Second International Conference on Environmental Toxicology brought
together a wide range of people working within the many disciplines
associated with environmental toxicology and hazards waste management, including: biologists; environmental engineers; chemists; environmental scientists; microbiologists; medical doctors; and all academics, professionals, policy makers and practitioners. This book contains the papers presented at the Conference and covers subject areas such as: Risk assessment; Effluent toxicity; Pharmaceuticals in the environment; Genotoxicity; Bioaccumulation of chemicals; Monitoring, assessment and
remediation of hazardous waste; New trends in environmental toxicology; Bio tests; Biodegradation and bioremediation; Ecotoxicity of emerging chemicals; Soil ecotoxicity; Protyomics and gemomics; Biological effects monitoring; Endocrine distribution in wildlife; Laboratory techniques and field validation; Online toxicity monitoring; Ecosystem and human health assessment; Exposure pathways; Integrated approach to risk assessment; Bio-terrorism safety and security; Habitat destruction. ... Read more

Product Description
Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the lung as nanoparticles have the potential to translocate to the bloodstream, the brain, and other target sites. The new questions posed by nanoparticles underscore the importance of interdisciplinary research and exchange and highlight the need for new collaborations among disciplines in medicine, toxicology, chemistry, and material sciences. 

Particle Toxicology brings together the state of the science in particle physico-chemistry, cell biology, and toxicology in a single volume. While organized around the classical toxicology paradigm of exposure - dose - response, the book is unique in its emphasis on mechanistic toxicology. Preparing the reader with a brief historical overview and a conceptual framework for particle research, the book provides reviews on the mechanisms and properties of pathogenic particles and their effects on target cells at various sites in the body. The text describes how adverse effects are a consequence of deposition, translocation, and the complex issue of “dose” dominates. Contributions from leading researchers address particle-associated pro-inflammatory effects and inflammatory signaling, cellular and extracellular oxidative and nitrosative stress, particulate interactions in the pulmonary, cardiovascular, and central nervous systems, as well as genotoxic effects. Exemplar particles include quartz, asbestos, particulate material and nanoparticles. The book also covers mathematical modeling and human studies as avenues for future research.

Responding to the evolving trend of consumer applications for particulate matter, Particle Toxicology provides the comprehensive resource for current knowledge from which to develop new concepts to understanding particle actions, measurement, testing, and pathogenic exposure to fine and ultrafine particles. ... Read more

Product Description
Encompassing 150 articles written by leading scientists in the field, the third edition of General and Applied Toxicology provides a comprehensive and in-depth review of the basic science of toxicology, its specializations, and the application of toxicological knowledge.

This new edition reflects developments within the field that have taken place since the second edition was published in 1999.  These include:  

• New information developed in the areas of both the fundamental and applied aspects of toxicology
• Considerable increase in the development of fundamental information and its applications, refinement of technical methods, advances in mechanistic toxicology, and greater interest in areas of toxicology previously regarded as of limited scope
• Changing approaches to methodological, interpretative, regulatory, and ethical aspects of basic and applied toxicology

General and Applied Toxicology, 3^rd Edition is the first port of call for academic researchers, industrial researchers, regulatory professionals, and advanced students looking for timely and authoritative information in the field. Due to the increase in public and media interest in exposure to toxic substances, this provides an indispensable general reference source for general physicians, lawyers, law enforcement agencies, information resource facilities, and members of the general public. ... Read more

Product Description
This book covers all aspects of toxicology, including toxic diseases of large animals, small animals, and exotic pets. It provides key information on how poisons affect the body, how the body responds to a foreign substance, how poisonings are diagnosed, and how poisonings are treated.

Coverage includes every organ system of every species of animal with details on each body system's susceptibility to poison. Poisons affect animals differently depending on species, breed, age, gender, health status, and reproductive status. This resource addresses these differences, allowing the veterinarian to determine the class of toxicant, the mechanism of action, and the proper course of treatment. If confronted with an unknown poison, the information in this book will assist the veterinarian in formulating a list of potential poisons based on the clinical signs that the animal is exhibiting, and in choosing the appropriate tests to narrow the list to one or a few possible poisons.

* Most comprehensive toxicology book available
* Written in a user-friendly style that makes it easy to master the content
* Covers poisonings in both large and small domestic animals
* The Principles of Toxicology section provides comprehensive coverage of concepts & terminology, toxicokinetics, treatments, and regulatory information
* The Manifestations of Toxicoses section is devoted to differentiating between poisons based on lesions and clinical signs
* The Classes of Toxicants section offers detailed information on each poison, including sources, risk factors, pathophysiology, clinical signs and lesions, diagnostic testing, and treatment
* The author is board-certified in toxicology, and the contributors are all toxicologists and educators, ensuring authoritative, up-to-date clinical information ... Read more

Customer Reviews (1)

Best Veterinary Clinical Toxicology Book Available.
Reasons this is the bestv vet clin tox reference book:
1. Concise information- no unnecessary wording
2. Up to date information with current standard of care treatment
3. Edited by THE expert in clinical veterinary toxicology ... Read more

Product Description
The Dose Makes the Poison A Plain-Language Guide to Toxicology Second Edition M. Alice Ottoboni Increasing media coverage of reports on the effects of chemicals, new recognition within government and industry of the need to protect against exposure, and other current issues are elevating the public’s concern about the health effects of synthetic chemicals in our environment. Unfortunately, much of this concern is based more on sensational news reports and half-truths than on scientific facts. This second edition of a widely read and highly acclaimed work reviews and explains the facts of chemical dangers in a clear and understandable manner. It objectively discusses the factors determining whether chemicals in our air, food, and water are harmful or harmless, and puts the dose - response relationship of chemicals in proper perspective. Effects of chemicals encountered at home and at work are presented in layman’s language to assure understanding without having to turn to other references. Thoughtful discussions of controversial issues help you to understand news media reports on toxicology, avoid the half-truths that lead to "poison paranoia," and make informed judgments about our use and control of chemicals. Extensively revised, the second edition is also reorganized to expedite access to specific information. All experimental and analytical methods are in one section, and references to the origins of toxicology and regulation of chemicals are in another separate section to improve ease of reading. In addition, coverage of subjects such as public distrust of science, epidemiology, reproductive toxicology, and risk have been expanded to provide a better understanding of the relationship of toxicology to current environmental problems. All aspects of exposure and its effects are reviewed, including

• How chemicals cause harm—toxicity, sensitization, corrosiveness, irritation, radioactivity, and other properties
• Routes of exposure—skin, inhalation, oral, and combinations
• Factors that influence degree of toxicity—species, age, sex, nutrition, state of health, presence of other chemicals, adaptation, and possibly, light
• Chemicals that cause cancer and birth defects

Customer Reviews (1)

Useful book, plodding effort
Dr. Ottoboni has two simple objectives in writing this book: to descibe the basics of toxicology and to refute unscientific views about chemicals and their toxicity that lead to unwarranted scares. She accomplishes her goals, but with some discomfort for the reader. Her style is that of a didactic bureaucrat and there are many words that could have been trimmed by an assertive editor. Considering the technical nature of the book and its many scientific assertions, it is inexcusable that the book has no footnotes. Apparently the reader is supposed to accept her declarations at face value. Ottoboni occasionially falls into a trap that she herself warns against by commenting about issues on which he has no expertise. She says, for instance, that the "medical profession now generally accepts the premise that stress can exert a profound influence on the course of many illnesses. Stress can actually be an etiologic (causitive) agentfor some cases of such diseases as high blood pressure, ulcers, allergies, colitis, and even cancer." Unfortunately for her, the fact that it was generally accepted did not make it true that ulcers are caused by stress. They are now known to be caused by a bacteria and the former claim that they were caused by stress is a major embarassment to medicine, which made this bogus claim in lieu of proof. It is also highly contestable that the other diseases she names are actually caused by stress, and she offers no evidence for her claim. (Medicine has a tragic history of attributing many diseases to emotional disorder, not the least of which was epilepsy, but Ottoboni shows no awareness of this.) Ottoboni should have restricted herself to what is proven, not what is "accepted." When she writes that "an authority in one field is not, of necessity, an authority in all of the others" she should have understood that that also applies to herself. Instead of this expensive book I would suggest a couple of very well written and documented books that go at the same issues from different perspectives. The first is Edith Efron's "The Apocalyptics : How Environmental Politics Controls What We Know About Cancer," and the second is the recent book, "The Skeptical Environmentalist," by Bjorn Lomborg. Both are superb, readable and worth buying. Borrow the Ottoboni book from the library. ... Read more

Product Description
This scarce antiquarian book is a selection from Kessinger Publishings Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the worlds literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of interest for everyone! ... Read more

Product Description
In Two Volumes. Other ISBNs In This Set Include: 1430485353. This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature. ... Read more

Product Description
In Two Volumes. Other ISBNs in this set include: 1432513168. This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature. ... Read more

Product Description
LOCATE FREQUENTLY USED INFORMATION EASILY AND QUICKLYWorking in the laboratory or office, you use a diverse assortment of basic information to design, conduct, and interpret toxicology studies and to perform risk assessments. The Second Edition of the best-selling Handbook of Toxicology gives you the information you need in a single reference source. NEW IN THIS EDITION:"Expanded coverage of inhalation toxicology, neurotoxicology, and histopathology "Additional regulatory chapters dealing with pesticides, medical devices, consumer products, and world-wide notification of new chemicals"Areas of toxicology missing from the first edition such as ecotoxicology and in vitro toxicology"A chapter providing extensive overview of the toxicology of metals"Two chapters on basic male and female endocrinology and related toxicology"Information on differences in physiological and biochemical parameters between children and adults"References to Web site sources of valuable information"Over 200 new tables and figuresTHE SINGLE SOURCE FOR THE INFORMATION YOU USE MOST FREQUENTLYUpdated and expanded, this unique book includes practical reference information useful to toxicologists in the chemical and pharmaceutical industries, contract laboratories, regulatory agencies, and academia. To help you find information quickly and easily, data is arranged by toxicology subspecialty and each chapter begins with a detailed listing of information presented. Containing over 700 tables and figures, Handbook of Toxicology, Second Edition gives you a single source for the information you use most often. ... Read more

Product Description
This unique resource introduces the fundamental principles and current concepts of toxicology and risk assessment offering comprehensive discussions on clinical testing, risk assessment of chemicals and hazardous materials, the application of animal data to human health risk assessment, mathematical models, statistical approaches, environmental laws, information resources, and risk management. ... Read more

Product Description

This leading textbook in the field examines the mechanisms underlying toxicity, particularly the events at the molecular level and the factors that determine and affect toxicity. The new edition is updated to reflect the latest research into the biochemical basis of toxicology and the growing concerns over the adverse effects of drugs, environmental pollution, and occupational hazards.

Principles of Biochemical Toxicology, Fourth Edition thoroughly explains dose-response relationships, disposition and metabolism, and toxic responses to foreign compounds, and presents detailed examples to make the mechanisms of toxicity more accessible to students encountering the subject for the first time. Comprehensive in scope with a clear and concise approach, the text includes summary sections, questions and model answers, and thoroughly revised artwork that serves as an essential aid to learning and teaching.

New to the Fourth Edition:

• reorganized sections that cover basic principles followed by sections on different types of toxicity
• extensive use of examples throughout and numerous explanatory diagrams
• new material on risk assessment, export systems, oxidative stress, Thalidomide, Tamoxifen and asbestos proliferators, domoic acid, bone marrow (benzene), heart (adriamycin), blood (primaquine), biomarkers, cytochrome P450 and other enzymes, receptor mediated effects, endocrine disruption, ethanol, botox, arsenic, and more
• questions with answers for each chapter for review and self-checking
• expanded and updated chapter bibliographies

Product Description
Food and Nutritional Toxicology provides a broad overview of the chemicals in food that have the potential to produce adverse health effects. The book covers the impact on human health of food containing environmental contaminants or natural toxicants, food additives, the migration of chemicals from packaging materials into foods, and the persistence of feed and food contaminants in food products. Chapters address the adverse effects of nutrient excesses, the impact of contaminants on nutrient utilization, metabolism of food toxicants, and the relationship of the body's biologic defense mechanisms to such toxicants. The book includes discussions on the risk determination process, food safety regulation, and the current status of the regulatory processes.Presenting the general principles of toxicology, this authoritative reference enhances the understanding of foodborne intoxications, infections, and diseases linked to foods. This in-depth study establishes a solid background in the principles and prevention of foodborne disease and the regulation of food safety. ... Read more

Product Description
This text is divided into three parts. The first part describes basic toxicological concepts and methodologies used in aquatic toxicity testing, including the philosophies underlying testing strategies now required to meet and support regulatory standards.
The second part of the book discusses various factors that affect transport, transformation, ultimate distribution, and accumulation of chemicals in the aquatic environment, along with the use of modelling to predict fate.; The final section of the book reviews types of effects or endpoints evaluated in field studies and the use of structure-activity relationships in aquatic toxicology to predict biological activity and physio-chemical properties of a chemical. This section also contains an extensive background of environmental legislation in the USA and within the European Community, and an introduction to hazard/risk assessment with case studies. ... Read more

Customer Reviews (1)

An Educational Asset To The Field Of Aquatic Toxicology.
This textbook is literally a constructivepiece of scientific genius. Rand is perhaps one of the most knowledgable and most well respectedauthorities on Aquatic Toxicology and its many subdisciplines.

Afterpersuing through the first few chapters of this wonderfully writtenscientific text, one becomes very interested and more hungry for knowledgedealing with this subject.Unlike many other novels of this nature, thisone is very unique in that it gives the read a clear and very indepthpicture of Aquatic Toxicology and its impacts on the environment as awhole.

This text deals with aquatic toxicology from an environmentalpollution aspect dealing with manmade and natural chemical toxicants. Italso deals with the ecotoxicity affects of man-made pesticides when aquaticorganisms are involved in the bioecologicall food-chain.

In short one cansoon surmise that this text is an ideal educational asset for all who aredesiring a more comprehensive background and informative session in thefield of aquatic toxicology and its subdivision.It is superbly writtenand it details every single aspect of toxicological studies dealing withaquatic organisms in their environmental setting. ... Read more

Product Description
This first comprehensive treatment of the subject for more than a decade includes the latest research on nanoparticle toxicology. The practical handbook addresses all areas where toxic mixtures are encountered, from environmental via occupational to medical settings, giving special consideration to air and water, and to the specific requirements for study design in mixture toxicology. While no extensive prior knowledge or toxicological experience is required, the practice-oriented case studies and examples in the second part make this the ideal companion for the professional toxicologist in industry or healthcare institutions with little time for academic study. ... Read more

Product Description
A comprehensive analysis of state-of-the-art molecular modeling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals

This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins. It covers the in vitro models used, newer technologies, and regulatory aspects. The book offers a complete systems perspective to risk assessment prediction, discussing experimental and computational approaches in detail, with:
*

An introduction to toxicology methods and an explanation of computational methods
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In-depth reviews of QSAR methods applied to enzymes, transporters, nuclear receptors, and ion channels
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Sections on applying computers to toxicology assessment in the pharmaceutical industry and in the environmental arena
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Chapters written by leading international experts
*

Figures that illustrate computational models and references for further information

This is a key resource for toxicologists and scientists in the pharmaceutical industry and environmental sciences as well as researchers involved in ADMET, drug discovery, and technology and software development. ... Read more

Product Description

Examining the complex interactions associated with clinical toxicological events and chemical exposure of drug administration, this updated and revised Second Edition functions as a stand-alone text or reference of clinical toxicology for professionals, students of toxicology and pharmacy, as well as forensic toxicologists, occupational healthcare workers, industrial hygienists, and safety engineers. This all-inclusive source has been updated to include the latest issues and the most current research in clinical toxicology.

Key features in Clinical Toxicology: Principles and Mechanisms include:

• Convenient and organized categorization of compounds into therapeutic and non-therapeutic agents
• Tables, drawings, and figures that provide readily accessible, precise data
• Tables for easy usage and cross-reference to names, indications, effects, adverse reactions, and drug interactions for over 70 common herbal products
• The brand, generic, and street names of therapeutic agents

Topics covered in the Second Edition include:

• Symptoms of diseases and pathology caused by toxins and clinical drugs
• Biological and chemical toxins, changes in protocols for managing toxic ingestions, new antidotes, changes in treatments, and the pharmacology and toxicology of herbal products
• The effects of biological and chemical agents cited by the U.S. and U.N. as potential bioterrorist weapons
• General physiology and pharmacology principles
• The widely distributed chemical agents and currently used therapeutic drugs that have hazardous effects

Product Description
REAL-LIFE CASES, TUTORIAL QUESTIONS, NARRATIVE HISTORYIntriguing anecdotal pedagogy, like the alleged arsenical poisonings of Napoleon and President Taylor and the probable mercury overdose of Isaac Newton, is one of the things that set Toxicology: A Case-Oriented Approach apart from other toxicology texts. Based on an undergraduate-graduate combined toxicology course at West Chester University, this innovative text captures readers' interest by combining modern case studies, historical cases, and hundreds of illustrations and tables. Each chapter presents several case scenarios that involve the reader with questions about diagnosis, testing methods, treatment, and other pertinent information. TOXICOLOGY FOR THE LABORATORY AND THE EMERGENCY ROOMIn an easy-to-read style, this book covers the major organ systems and reviews the effects of toxins in each system. Most contemporary books are almost entirely clinical or entirely analytical. Toxicology: A Case-Oriented Approach treats each area extensively to benefit students and professionals who need to know aspects of both. It describes diagnosis and treatment of each specific poisonous exposure and discusses chemical basis and the laboratory testing of toxins. This dual perspective, coupled with the book's interesting narrative approach, lets readers quickly absorb the information they need to understand toxicology in the laboratory and in the Emergency Department. ... Read more

Customer Reviews (2)

forensic toxicology
i am very pleased with my copy of this text. i did choose to buy it new because i wanted to make my own markings and my not have to worry about anyone else's work. i am surprised that the book did come as quickly as it did. i opted for the free shipping and i received the book in 3 days instead of the indicated 5-9. thanks amazon!

A good start
This text book is a great starting book in the field of toxicology.I am a new student to this field. The author's combination of clinical and technical knowledge makes this book all the more interesting. ... Read more

Product Description

Herbal Products: Toxicology and Clinical Pharmacology, Second Edition builds on the informative foundation laid by its predecessor. This fully revised and expanded second edition boasts more than 200 new references that document efficacy studies and adverse effects and four new chapters devoted to dietary products. Practitioners and researchers will find that this volume is a comprehensive resource for objective clinical information.