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This is Volume 4: Autocoids, Diagnostics, and Drugs from New Biology, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Peptide and Protein Hormones, Peptide Neurotransmitters, and Therapeutic Agents, Vitamins and SNPs: Single Nucleotide Polymorphisms and Pharmacogenomics.

To purchase the entire 6 volume set, please refer to ISBN 0-471-37032-0. ... Read more

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Opening with a general introduction on chemokine function and chemokine receptor biology, the handbook goes on to cover the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including HIV/AIDS. The second half of the book systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners. Contributions in the first part of the book are mainly from academia, whereas the second part contains up-to-date reports from the pharmaceutical industry. ... Read more

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Antitumour chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells. These therapies are in their infancy, but they hold promise of more effective therapies with fewer side effects. Resistance to antitumour drugs is another important but normally neglected field. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumour drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumour agents, aiming at the rationalization of the action of this type of drugs, which would allow the design of new active structures.

* Presents information in a clear and concise way using a large number of figures
* Historical background provides insights on how the process of drug discovery in the anticancer field has evolved
* Extensive references to primary literature ... Read more

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Ion channels play a vital role in basic physiological functions such as generation of electrical activity in nerves and muscle, control of cardiac excitability, intracellular signaling, hormone secretion, cell proliferation and many other biological processes. Because of their prevalence and the critical role they play in virtually all tissue types and organs, ion channels are also involved in a number of pathophysiological conditions. The aim of this volume is to review recent advances in the field of ion channel related diseases. Following an overview chapter summarizing the current state of ion channel screening technologies, five topics covering areas such as cancer, cardiac arrhythmias, cystic fibrosis, and pain have been selected, and the current state of knowledge is presented by leading experts in their field. Each chapter is structured to cover the biological rationale for the target, the current status in the development of agents to treat the disease, and future prospects and challenges facing each therapeutic area. The reader will receive a critical overview covering the progress made in the rapidly developing and complex field of ion channels and diseases.

Product Description
This book, a compilation by experts in the field, is designed to provide an introduction to the area of medicinal inorganic chemistry and to summarize current, state-of-the-art developments in the field.Medicinal inorganic chemistry represents a key thrust area in medicine and biological inorganic chemistry.It is one of great current excitement and achievement. The field of metals in medicine represents an approximate $3 billion dollar a year industry, with successes in the area of Tc- and Gd-based imaging agents and Pt-based cancer therapeutics being major contributors to this bottom line. It has become increasingly apparent, however, that metal-based pharmaceuticals can play a prominent role in areas outside of imaging and oncology, including in those associated with the diagnosis and treatment of metabolism- and genetic disorders, cardiovascular disease, gene therapy, inflammation, reperfusion injury, stroke, diabetes, ALS, malaria, and neurological disease to name but a few.A objective of this book, therefore, is to highlight these opportunities for future advances and to foster further interactions between those working in the metal-based drug development, including imaging agents, and those engaged in the more classic pharmaceutical industries. ... Read more

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Self paced study review of organic functional groups for pharmacy students. DNLM: Chemistry, Organic. ... Read more

Customer Reviews (9)

Average book
This book is helpful for an organic chemistry class, maybe for a review to strengthen your organic chemistry background for a pharmacology course or pharmacy school.

Good, solid Organic Review
I purchased this in order to prepare myself for an medicinal chemistry course, and was able to chew through it slowly in about 2 weeks.I have not had organic chemistry in 3 years, and it was a fantastic source for bringing old knowledge, and some new, to the forefront of my mind.

Save the money, use it towards the purchase of a Medicinal Chemistry Book
This book is good if you want a quick read on FGs in Medicinal Chemistry, you can read it in 3 sessions and pick up some concepts here and there, but you will need to look in other places to expand your knowledge more in depth.For that, I would rather save the money and use it towards the purchase of a good medicinal chemistry book, where you will find the same information and more.... don't get me wrong, this book here is perfect if you have to travel or commute to work by bus or train and need some reading, but to learn beyond it, then this is not for you,

Decent book
I had to purchase this book for a Principles of Drug Action class in pharmacy school.The book is pretty easy to read but very brief on all topics.This makes for a quick read but if you don't understand a topic, you will have to look elsewhere because there is simply not much 'depth' here.Overall a good review if organic is fairly fresh and will probably serve as a good primer but you will need other texts for depth.

Great OChem Review
I am currently in pharmacy school and we recently had a class about medicinal chemistry.I have not had organic chemistry or used topics pertaining to in over 2 years.Our instructor rccommended this book and the layout is easy to follow and to understand.I wouldn't use this if you are just starting organic chemistry, but more so as a review for further graduate level courses. ... Read more

Product Description

Metals in pharmaceuticals have played an increasingly important role in medicine over the last century, particularly in cancer therapy and diagnostic imaging methods. Medicinal Applications of Coordination Chemistry focuses on the role that transition metals play in clinical applications.

Medicinal Applications of Coordination Chemistry begins with a brief historical review and an introduction to the chemistry of d- and f- block metals. Subsequent sections discuss metallodrugs for a number of different applications, the design of new drugs and the relationship between structure and function. Key sections include diagnostic applications of metal compounds in anatomical and functional imaging, and therapeutic applications of metals compounds.

This book is ideal for researchers in academia and industry and comes complete with examples of real life applications.

Product Description
Fueled by the expertise of a team of international specialist authors, this first reference on the booming topic covers everything a drug researcher needs to know about targeting epigenetic mechanisms of disease.
The first part of the book surveys current methodologies for finding and validating drug candidates that act via epigenetic mechanisms. The second part systematically surveys known and suspected drug targets within the epigenetic machinery, including the discovery and development of vorinostat, the first marketed epigenetic drug.
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Product Description
In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything from the fundamental principles right up to the impact of pharmacokinetic parameters on the discovery of new drugs.

While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. ... Read more

Product Description
A state-of-the-art collection of detailed synthetic procedures that lead to a variety of scaffolds, turn mimetics, peptide-bound replacements, and enzyme inhibitors. Topics range from unusual syntheses of amino acids to the use of a variety of linear and heterocyclic scaffolds in place of the peptide backbone. Important chemical procedures and methods include the transient protection of charged peptides as neutral prodrugs for improved blood-brain penetration and the replacement of peptide bonds with heterocyclic rings, olefins and fluoroolefins, and ketomethylenes. Synthetic protocols towards the transition-state mimics and reactive "warheads," applicable in enzyme inhibitors, are also disclosed.

... Read more

Product Description
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

* Covers findings related to cardiovascular, inflammation, and pulmonary diseases

* Examines issues in oncology, from mTor inhibitors to drug targets

* Incorporates up-to-date information on drug design and discovery, including delivery to market ... Read more

Product Description
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

* covers findings related to cardiovascular, inflammation, and pulmonary diseases

* examines issues in oncology, from mTor inhibitors to drug targets

* incorporates up-to-date information on drug design and discovery, including delivery to market ... Read more

Product Description
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

* Covers findings related to cardiovascular, inflammation, and pulmonary diseases

* Examines issues in oncology, from mTor inhibitors to drug targets

* Incorporates up-to-date information on drug design and discovery, including delivery to market ... Read more

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Annual Review of Eclectic Developments in Medicinal Chemistry

Product Description
This volume provides reviews of six topics demonstrating the breadth of the field and recent successes in medicinal chemistry. Each of the first five chapters takes an important biochemical target as its theme and provides an insight into current progress in drug design.The last chapter focuses on the vital subject of phamacokinetics and the great strides that have been made in this discipline during the past decade. All chapers provide an insight into the skills required of the modern medicinal chemist, in particular,the use of an appropriate selection of the wide range of tools now available to solve key scientific problems.

*Presents the latest research in the field of drug discovery
*Publishes on a twice yearly basis to bring you the most innovative updates in medicinal chemistry
*Available as an online resource via ScienceDirect ... Read more

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Recent advances in knowledge of the genetic makeup of viruses and the precise function of their proteins has led to the emergence of antiviral chemotherapy as a growing area of drug therapy. This introduction to the field covers: the discovery of nucleosides to combat Herpes virus infections; advances in the understanding of HIV in particular and of viruses in general, leading to a rapid increase in the number of experimental chemotherapeutic agents to treat HIV and other viral infections; progress in the treatment of viral respiratory ailments, such as the common cold and influenza; and the many viral agents resposible for hepatitis. ... Read more

Product Description

Annual Review of Eclectic Developments in Medicinal Chemistry