Product Description
In this third edition, the editors have accounted for the numerous changes in protocols for managing poison ingestions and have again provided an indispensable resource for all students of pharmacy and the health sciences on the basic principles of clinical toxicology. The book's unique focus on the fundamentals helps the reader understand why events occur and why a particular treatment is selected. Each chapter presents pertinent information on classes of toxic agents, their common sources and usual methods of intoxication, incidence and frequency of poisoning, mechanisms of action, clinical signs and symptoms of poisoning and management guidance. The text includes illustrative case studies, carefully selected to reinforce the information covered. Each chapter concludes with review questions to further enhance comprehension. ... Read more

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Univ. of Minnesota, Minneapolis. Review text features concise answers that include the author's pearls, tips, memory aids, and secrets. Bulleted lists, algorithms, and tables are included. For medical students preparing for exams or rounds. Softcover. DNLM: Toxicology--Examination Questions. ... Read more

Customer Reviews (2)

Excellent quick reference guide
I purchased this book to include in my library and to serve as a reference for lectures.I have found this book to be a superior guide for gaining the basic knowledge of the important topics in toxicology, without too much information.I very much enjoy all of the Secrets Series books that I have purchased (about 10 of them so far), but have found this one to be one of the best of the bunch.The concise nature of the various topics is put together very well and has many interesting "extra tidbits" that are great as "Did you know" facts for lectures.All major and many less common medications and environmental toxicities are covered.Definitely a great choice for the home or office library.

Excellent quick reference guide
I purchased this book to include in my library and to serve as a reference for lectures.I have found this book to be a superior guide for gaining the basic knowledge of the important topics in toxicology, without too much information.I very much enjoy all of the Secrets Series books that I have purchased (about 10 of them so far), but have found this one to be one of the best of the bunch.The concise nature of the various topics is put together very well and has many interesting "extra tidbits" that are great as "Did you know" facts for lectures.All major and many less common medications and environmental toxicities are covered.Definitely a great choice for the home or office library. ... Read more

Product Description
Parke-Davis Pharmaceutical Research, Ann Arbor, MI. Examines recent results of thirty years of research on calcium-activated-neutral protease (CANP or calpain). Addresses the pathophysiological role of calpain in various human disorders such as cerebral ischemia, traumatic brain and spinal cord injury, and more. For researchers. ... Read more

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Introduction to Biochemical Toxicology
Third Edition
Over the past several decades, biochemical toxicology has contributed greatly to the advancement of scientific disciplines ranging from medicine and pharmacology to environmental science and industrial hygiene. In its never-ending quest to define the biochemical, cellular, and molecular events occurring when toxicants interact with organisms, biochemical toxicology provides the rational basis for, among other things, our understanding of acute and chronic toxic processes, the development of new therapies, the determination of toxic hazards, and the development of medical and agricultural biocides.
Recent applications of new molecular and cellular techniques have greatly expanded our knowledge of how toxicants produce their adverse effects. As a consequence, the time has come for a substantial revision of Professor Ernest Hodgson's classic reference in the field. This Third Edition now contains updated overview chapters on immunochemical and molecular techniques. It also features entirely new chapters covering such crucial topics as immunotoxicology, cutaneous toxicology, reproductive and developmental toxicology, and molecular epidemiology. ... Read more

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Examines endocrine toxicology’s increased importance in environmental safety issues due to legislative directives established over the past ten years.

With contributions by international experts in academia, chemical manufacturing, government research laboratories, regulatory agencies, and private consulting, this guide explores the potentially damaging influence of environmental agents on the endocrine system.

Covering all principal areas of EPA concern, Endocrine Toxicology, Third Edition provides:

• putative endocrine disruptors and mechanisms of endocrine toxicity
• the history and status of the regulatory process
• mechanisms of toxic effects in various hormonal systems
• comparisons of the endocrine responses in humans, livestock, and wildlife
• testing methods in mammalian, fish, avian, and amphibian models
• valuable insight into the approaches of various personnel in the field, including: government officials who make and oversee policy; scientists in charge of development and validation of testing methods; basic researchers who identify toxic mechanisms; and manufacturers responsible for environmentally benign product certification

Product Description
The Toxicology Handbook provides you with quick access to common ingestions you're likely to see in the Emergency Department. Chapters covering Pesticides, Cardiovascular Drugs, Drugs of Abuse, and many more put essential topics right at your fingertips. Each chapter follows a similar organization, making information quick and easy to find.

• Bulletted format makes information easy to access and read
• Chapters follow the same organization - Introduction and Overview, Substances, Toxicity and Clinical Presentation, Laboratory Evaluation, Treatment, Special Considerations, Admission Criteria/Disposition, Pearls and Pitfalls, References/Suggested Readings - allows you to find information quickly
• Full of clinical pearls, including Toxicology Mnemonics and Acronyms, The Toxicology Lab, Antidotes, Street Names for Drugs of Abuse, and more!
• Chapters logically organized by types of drug like Pesticides, Cardiovascular Drugs, and Drugs of Abuse for ease of use.

Customer Reviews (1)

Toxicology Handbook for Clinicians
Needed a toxicology book that we could use in our medical clinic. Amazon was the only place to find the most current one available. It is also concise and easy to read. ... Read more

Product Description
Behavioural ecotoxicology is an emerging field dealing with the effects of environmental pollutants on the behaviour of animals. Behavioural techniques derived from experimental psychology, behavioural pharmacology and neurotoxicology are applied to detect and characterise changes in animals living in the environment exposed to various pollutants. Behavioural effects are then interpreted in an ecological context considering the long-term relevance of these changes at both the individual and population level.

... Read more

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Delineates risk associated with fire & explosions, chemical reactivity, coordinates chemical hazards data with relevant emergency response information. Defines key internationally used terms, in addition to those used by the U.S. Occupational Safety & Health Administration (OSHA) & evaluates personal protection methods & field monitoring instrumentation. ... Read more

Customer Reviews (1)

Cheremisinoff's Handbook of Industrial Toxicology
This is an authoritative, up-to-the-minute reference which provides vital safety information on over 1000 commercial chemicals. The volume exhaustively explores the current data on fire and chemical compatibility, response methods for incidents involving chemical spills and fires, and personnel and worksite safety monitoring and sampling. Shows professionals working with hazardous chemicals, how to prevent accidents, and how best to respond to accidents when they occur. The handbook draws on research from both industry and government. Also including: describes risks associated with fire and explosion, chemical reactivity, and long-term chemical exposure, coordinates chemical hazards data with relevant emergency response information, defines key internationally used terms, in addition to those used by the U.S. Occupational Safety and Health Administration (OSHA), outlines emergency medical protocols for dealing with chemical exposure, as well as procedures for containing an incident, highlights material safety data sheets (MSDS) that reflect actual practice of specific companies, evaluates personal protection methods and field monitoring instrumentation. This handbook has served as a major source of safe handling information that our company has used for numerous industrial consulting assignments. We have found this to be an invaluable reference for our technical library. ... Read more

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This is the final volume in a three-volume work that has addressed the scientific methodologies relevant to clinical neurobehavioral toxicology. Volume I focused on basic concepts and methodologies in Neurobehavioral Toxicology, with Volume II focusing on the peripheral nervous system. Volume III attends to what is known about industrial and environmental chemicals, medicines, and substances of abuse and how these agents affect the central nervous system. All substances have the capacity to be toxic, depending on factors that include the physical properties of the chemical or compound, organism related variables, or interaction between the two. These substances on the other hand and as a result of these same factors might be used therapeutically or even recreationally. The difference between medicine, recreational drug, or poison depends often on a careful balance between adverse and intended effects. How to determine that a specified substance has caused harm is emphasized in the present volume by way of case examples and discussion. Illnesses and behavioral variations that compete with toxicant-induced explanations for findings in a given case, as well as the various controversies that can arise around issues of diagnosis and causal determination, are treated comprehensively in this volume.

Product Description

Bringing together more than thirty influential regulators, academics, and industry scientists, Ecological Models for Regulatory Risk Assessments of Pesticides: Developing a Strategy for the Future provides a coherent, science-based view on ecological modeling for regulatory risk assessments. It discusses the benefits of modeling in the context of registrations, identifies the obstacles that prevent ecological modeling being used routinely in regulatory submissions, and explores the actions needed to overcome these obstacles.

The book focuses on the following issues:

• Uncertainties in the process of model development, such as design, analysis, documentation, and communication
• The availability of data and background information needed for optimal modeling
• The limited knowledge of modeling
• The lack of confidence in the outcome of ecological models and their reliability in pesticide risk assessment

It also suggests future solutions to these challenges, including:

• A guidance document on the modeling process
• Case studies that show how ecological models can provide reliable ecologically relevant risk assessments
• Training the people who generate or evaluate results obtained by ecological models

Focusing on ecological models, such as unstructured population models, stage-structured matrix models, and individual- or agent-based models, this volume helps regulatory authorities, manufacturers, and scientists assess the risk of plant protection products in nontarget organisms. Armed with this knowledge, readers will better understand the challenges of using ecological modeling in the regulatory process.

Product Description
Updating the extremely successful Wildlife Toxicology and Population Modeling (CRC Press, 1994), Wildlife Toxicology: Emerging Contaminant and Biodiversity Issues brings together a distinguished group of international contributors, who provide a global assessment of a range of environmental stressors, including pesticides, environmental contaminants, and other emerging chemical threats, and their impact on wildlife populations.

Addresses Emerging Wildlife Threats in One Concise Volume

A decade ago, many of these threats existed but were either unrecognized or considered minor issues, and all have now snowballed into major challenges for the conservation of wildlife populations. This is the first book to address these dangers in a single volume and recommend proven mitigation techniques to protect and sustain Earth’s wildlife populations.

Examines Species Range Shifts, Ocean Acidification, Coral Bleaching, & Impacts of Heightened UV Influx

This comprehensive reference identifies and documents examples of chemical stressor exposures and responses among ecosystem receptors worldwide. Chapters discuss emerging diseases and the expansion of pesticide/contaminant use, as well as agricultural trends and biofuels, and the widespread use of munitions and explosives from military and industrial-related activities. With the aid of several solid case studies, the book also addresses atmospheric contaminants and climate change, population modeling, and emerging transnational issues in ecotoxicology.

Wildlife Toxicology: Emerging Contaminant and Biodiversity Issues stimulates dialogue among the academic and research communities and environmental public policy decision makers. The book challenges these groups to think more globally about environmental contaminants and their potential impacts on biodiversity and environmental degradation.

Check out Ronald J. Kendall's Advances in Biological and Chemical Terrorism Countermeasures.

Professor Kendall has been quoted recently in several news outlets in connection with the Gulf Oil Spill. Check out these articles on the CRC Press Ning page. ... Read more

Product Description
Originally titled Handbook of Developmental Toxicology, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition is a guide for developmental and reproductive toxicologists. Completely revised and updated, new chapters cover genomics/preteomics, endocrine disruptors, testing for male reproductive toxicity, and testing for female reproductive toxicity. It covers evaluating and interpreting data. Both practical and informative, the book bridges the gap between theory and application. It contains insights gained from hands-on experience and gathers information scattered throughout the literature into one reference. ... Read more

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This introductory text addresses the principles and mechanisms of toxicology as applied to environmentally-encountered toxic agents. Each chapter concludes with review questions that may be used for student self-testing and topics covered include dose response, hazards and risk assessment, determination of toxicity, pesticides, metals, plastics, organic solvents, environmental carcinogens, teratogens and mutagens. ... Read more

Customer Reviews (1)

Simply Outstanding And A Credit To Environmental Toxicology
After thoroughly perusing the pages of this textbook, it became clearly that the author, W. W. Hughes,touches on every topic and subtopicassociated with the discipline of Environmental Toxicology.

Unlike othertextbooks dealing with the same scientific discipline,Hughes does notappear to be unitalented or uniknowledgable when dealing with thediscipline of environmental toxicology. Rather, Hughes shows that he isvery knowledgable aboutthisdiscipline as well as its many subareas andtopics.This textbook touches on everyarea and related subarea ofenvironmental toxicology from organ toxicity and specificty tothe finercomponents of a detailed and scientifically adequate riskassessment.

Moreover, the author breaks down the various classes ofenvironmental pesticides for the reader in terms of names, biochemicalclass,solubility in water, and their Modes of Actions on terrestrials,aquatic, and invertebrate species.

This textbook is a must for anystudent, instructor, government biologist/chemist/toxicologist, orindustrialist desiring a more indepth and perhaps more scientific knowledgeabout the components which are used in the discipline of environmentaltoxicology.

Hughes makes sure this textbook stands out as an informativescience novel from an environmental point of view. It is a must-readtextbook that will definitely hold the reader's interest for a long periodof time. ... Read more

Product Description
The "ULLA" series is a new and innovative series of introductory textbooks for postgraduate students in the pharmaceutical sciences. This new series is produced by the ULLA Consortium (European University Consortium for Advanced Pharmaceutical Education and Research). The Consortium is a European academic collaboration in research and teaching of the pharmaceutical sciences that is constantly growing and expanding. Before a drug substance can be tested in man, a set of toxicology studies must be carried out in animals and in vitro to ensure, as far as possible, safety for the test subjects. Toxicity studies involve assessment of acute, repeated dose and chronic toxicities, evaluation of potential effects on vital organs, reproductive and developmental toxicity studies, and carcinogenicity studies. This book covers a limited number of areas of drug toxicity which address the major issues including registration requirements of new drugs and pharmacovigilance. It also provides an overview of the methodology and requirements of pre-clinical safety assessment of new medicines.Mechanisms by which drugs cause toxic effects in living organisms, and problems in the toxicity of specific agents are covered, as are regulatory issues, pharmacovigilence, and clinical toxicology. There is no other textbook at this level dedicated to pharmaceutical toxicology, and this new title in the "ULLA" series fills a definite gap in the market. ... Read more

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The only up-to-date compilation of renal methods available, this book is the definitive resource for any renal researcher eager to stay ahead. Methods in Renal Toxicology presents a vast array of methods for the study of renal cellular and tubular structure, function, and biochemistry under physiological, toxicological, and pathological conditions. It provides detailed descriptions in easy-to-understand language of methods designed to enhance your research efforts.Methods in Renal Toxicology puts you on the cutting edge with valuable chapters detailing molecular methods and transgene and gene targeting - the most recent approaches to the study of renal toxicology. Overall, the book's topics range from non-invasive assessments of renal function in the whole animal and clinical settings to cellular and molecular approaches. Specifically, the book delves into measurements of clearance and urinary markers, histopathology, and methods to assess renal carcinogenesis, mutagenesis, oxidative stress, mitochondria injury, cellular repair, and drug metabolism and transport. A variety of in vitro methods are also described, including the isolated perfused kidney, micropuncture, microperfusion, microdissection, renal slices, isolated perfused tubules, suspensions of tubules and isolated cells, and primary cell cultures and cell lines. Methods in Renal Toxicology is a must-have resource for all renal investigators. Nowhere else can you find concise descriptions of traditional and up-to-the-minute renal toxicology methods in such a practical, well-written single-volume guide. ... Read more

Customer Reviews (1)

renal toxicology
i love renal toxicology and i want to have much more knowledge about in ... Read more

Product Description
Univ. of South Florida, Tampa. Concise text has been expanded to include information about the mechanisms of chemicalinduced injury and carcinogenesis. For practitioners and students. Previous edition: c1983. 27 contributors, 26 U.S. DNLM: Hazardous Substances--toxicity. Added to Brandon-Hill Medical List in April 2001. ... Read more

Customer Reviews (2)

Good Job!!
I am very please with the service.The book was ordered Fri. evening and arrived Monday afternoon.Great service!!
Thanks

Valuable Reference
This text is a valuable reference for industrial chemicals. ... Read more

Product Description
This revision of the highly acclaimed Hayes' Handbook of Pesticide Toxicology is an in-depth, scientific sourcebook concerning use, properties, effects, and regulation of pesticides.This edition is a comprehensive examination by international experts from academia, government research, and the private sector of critical issues related to the need, use, and nature of chemicals used in modern pest management.This two-volume set contains up-to-date information on a broad range of topics which establishes context of pesticide use and outlines how they are scientifically evaluated.
Experts from a variety of disciplines contribute to this work.Some provide a fresh look at existing information, and others look ahead at issues that are central to understanding pesticide use and toxicology in modern integrated pest management.

Key Features
* Establishes a context for evaluation of pesticide use in agriculture, residential pest control and public health described
* Important discussion of strategies for pesticide risk assessment
* All major classes of pesticide considered
* Different routes of exposure critically evaluated
* Current regulatory issues defined
* Emerging issues concern topics of special relevance in the future
* Agents reviewed by experts from academia, government research, and the private sector ... Read more

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National Veterinary School of Lyons, France. Translation of a quick-reference guide on the diagnosis, treatment, and management of animal poisoning, for veterinary surgeons. Approximately 400 entries on toxic substances including plants, mycotoxins, chemicals, and more. Softcover. ... Read more

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This book stems from the belief that scientists and policy makers should be guided by the most reliable predictive models available, among which the hormetic dose response model has considerable evidence to support it, is very generalizable, has a strong mechanistic foundation and can be applied in the assessment of single agents and complex mixtures. For these reasons, the hormetic model should become the default in risk assessment.

This book summarizes and analyzes the various positives of hormesis in an attempt to revel hormesis as a fundamental principle of toxicology, biology, and biomedical sciences as a whole. A focused discussion of how acceptance of the hormedis based model of toxicology would affect environmental standards and clean up values is mounted. A panel of scientists has been recruited to critically evaluate the hormetic dose response model and its comparison with current default models in their individual fields, including cellular biology, evolutionary biology, gerontology, and pharmacology. In-depth investigations are provided into how biological systems respond to increasing doses of environmental toxins while attempting to understand how cells respond to stress in the contexts of aging and neurological disorders.