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This digital document is an article from Journal of Law and Health, published by Cleveland Marshall College of Law on March 22, 2001. The length of the article is 3877 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Genomic medicine: the human genome project from a healthcare provider's perspective.(Is There a Pink Slip in Your Genes? Genetic Discrimination in Employment and Health Insurance)(Transcript)
Publication: Journal of Law and Health (Refereed)
Date: March 22, 2001
Publisher: Cleveland Marshall College of Law
Volume: 16Issue: 1Page: 33(6)

Article Type: Transcript

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This digital document is an article from Human Ecology, published by Cornell University, Human Ecology on March 22, 2001. The length of the article is 514 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Genomics and Human Ecology.(Brief Article)
Publication: Human Ecology (Refereed)
Date: March 22, 2001
Publisher: Cornell University, Human Ecology
Volume: 29Issue: 2Page: 1

Article Type: Brief Article

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This digital document is an article from Family Practice News, published by International Medical News Group on March 15, 2010. The length of the article is 951 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.

Citation Details
Title: Meet NHGRI's new director.(GENOMIC MEDICINE)(National Human Genome Research Institute's Dr. Eric D. Green)(Interview)
Author: Greg Feero
Publication: Family Practice News (Magazine/Journal)
Date: March 15, 2010
Publisher: International Medical News Group
Volume: 40Issue: 5Page: 62(2)

Article Type: Interview

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Product Description
From the moment men first began to contemplate their world, three questions have occupied the human mind: Where do we come from? What are we? Where are we going? Artists (notably Paul Gauguin), religious thinkers, philosophers and, most recently, scientists have all searched for answers. This book describes molecular evidence for human descent from the first single-celled organisms all the way to the emergence of Homo sapiens. After distinguishing myth from science, the authors introduce molecular evolution and the molecular approach to the study of human origins and draw conclusions about human identity.

Unique features of this book include:

* A concentration on information provided by molecules, first and foremost nucleic acids, unlike most books on evolution, which focus solely on testimony provided by archeology. * Clear explanations of difficult concepts, including mathematical formulas, thus allowing readers to understand without prior knowledge of the subject.* Over 120 detailed figures, illustrations and tables that enhance the text.* A glossary of terms that are highlighted in the text.* Sources for further reading and reference.

The authors describe how scientists decipher human origin from the record encrypted in the DNA and protein molecules, and point out the limitations of ancient DNA analysis. They deal with the concept of race from the point of view of what is now known about human variability, and distinguish between views colored by "political correctness" and views based on objective evaluation of the data. Finally, the book warns the reader that knowledge of man's place on the Tree of Life can change our philosophical and ethical perspective, and considers what the future of the human race may entail ... Read more

Customer Reviews (4)

Fascinating book.
This is a wonderful book on the fascinating subject of human origins and evolution written by two experts in the field. It is a journey though many aspects of evolutionary biology butfocusingon the mind-boggling developments in molecular biology.A rare and refreshing qualily of the book isthat the authors try always to give a balanced and critical discussion of the hypothesisat stake, their strenghts and weaknesses.

Some parts of the book are quite technical but worth the effort. In any case, one should praise the authors for their courage in trying to explain some of the complex science and mathematics involved in the field.Though this inevitably has shortcomings, it is infinitely better than the usual path of oversimplification and white-washing, fashionable in many science books nowadays.

This should be the most widely read book on human evolution
Klein and Takahata present a very readable account of the hard science and mathematics that underlies what Nobel laureate James D. Watson, co-discoverer of the molecular structure of DNA, has come to refer to as the "law of evolution".The title of the book comes from the Gauguin painting "Where do we come from?What are we?Where are we going?"As pointed out in the text, science has essentially answered the first question.

Although popular books meant for a lay audience abound in the literature, and are often quite well written, they shy away from the rigorous underpinnings of modern Darwinian evolutionary theory.Klein and Takahata give the reader the details needed for an understanding of human evolution that goes beyond mere storytelling.They assume knowledge of mathematics and biology that we all were supposed to have learned in high school, and develop the remaining background in the course of the text.As a consequence, if you learn nothing else by reading this book, you'll learn some math and molecular biology that apply to things other than evolution.Hopefully, however, you'll come to understand that evolution is a fact which can't be invalidated by legal argument or religious sophistry, including the current shibboleth of "intelligent design."

human evolution explanation at its best
This is simply the best book i've found on human evolution. The subtitle is "The Molecular Evidence for Human Descent", don't be put off if you don't have a degree in biochemistry. Unlike most other technical and scientifically sophisticated books, in this one, the author holds your hand. He does it very well, introducing binominal and poisson distribution analysis both in the text and in appendices, for example. You are aware of his careful setting up the pieces that you need in order to understand the take home message of each chapter, and you are grateful, even if you already know the material, for the 'nice' way he does it. I finished the book wishing he would rewrite many biology and engineering textbooks i have been subjected to over the years by authors who assumed if you didn't know exactly what you were reading, then you shouldn't have bought and tried to read his book in the first place. For this characteristic alone the book is deeply and joyfully to be praised.

I am aware of the divisive character of the debate on human origins, this book will not settle it. But it will be a book that can be recommended to bring your reasonable intelligent but somewhat scientifically ignorant friend up to speed on the issues from a unabashed secular scientific viewpoint. It will, i would hope, set a standard for introductory books in the field. For if it can get a hearing, and even become popular then other authors will be forced to help people understand their arguments by giving them the tools to analyze and understand their positions, not just assume them.Now this doesn't negate the need to do your homework in order to be a serious student in any field, many things will take lots of reading to get the basis for advanced arguments. Something that will never be done in one, or even a set of books. But as the authors prove a reasonable grasp of human evolutionary arguments from a biochemical/genetic point of view is not that sophisticated of a field to require volumes, just this one.

Lest i miss an important issue, i would like to state that the author, like most secular scientific people makes the mistake of drawing metaphysical conclusions from scientific data. This i belief to be the problem of scientism, the unjustified extension of method-science into metaphysics or religion. The authors would certainly disagree with me. In any case, their philosophic position is clearly stated, open and presented in a manner that is not belittling of a religious prespective. So even if you are a theist i believe that there is much to be gained from reading this book, don't let the scientism put you off.

thanks for reading this review, and please get the book, it is certainly a most important topic, whether you agree with evolutionary analysis or not, you must be informed.

richard williams

A splendid book
This is a super-ambitious, yet superbly-done account of life on earth from the first primitive creatures down to you and me. It's quite technical, but as lucid as possible. And the equations, diagrams, and tables are interspersed with fascinating asides, such as full explication of the the Gaugin masterpiece that provides the title and cover picture. It also offers in passing the most interesting interpretation of the Garden of Eden and the serpent's offer from Genesis that I've ever read. ... Read more

Product Description

The problem many microbiologists face is simply that of too much information. This book details many published methods for comparison of genomes, and provides examples of how custom comparisons can be made. The choice of methods obviously depends on the questions to be asked, and of course on the quantity of genomes to be compared. Two similar bacterial chromosomes can simply be aligned with each other, and regions of inversions and deletions can be readily visualised. However, this method won’t work to compare hundreds of genomes, where 2-Dimensional clustering heat maps would be useful.

This text is built around teaching COMPUTATIONAL / BIOINFORMATIC methods for comparison of microbial genomes, and includes detailed examples of how to compare them at the level of DNA, RNA, and protein, in terms of structural / functional analysis.

Aimed at advanced undergraduate and graduate students in Bioinformatics and Microbiology, this book will prove an invaluable reference to computational and bioinformatics tools.

Product Description
This publication combines and extends the now classic system of human cytogenetic nomenclature prepared by expert committees and published in collaboration with Cytogenetic and Genome Research (formerly: Cytogenetics and Cell Genetics) since 1963. Revised and finalized by the ISCN Committee and its advisors at a meeting in Vancouver, BC, in December 2004, it updates, corrects and incorporates all previous human cytogenetic nomenclature recommendations into one systematically organized publication. It thus supersedes the previous compilations in "ISCN 1985" and its supplement, "ISCN 1991", the Guidelines for Cancer Cytogenetics, and "ISCN 1995". What's new in "ISCN 2005"? The G- and R-banded karyotypes have been replaced by new ones reflecting higher band-level resolutions. New ideograms at the 300-band and 700-band level have been added. The in situ hybridization nomenclature has been modernized, simplified, and expanded. New examples reflecting unique situations are included. A basic nomenclature for recording array comparative genomic hybridization results is introduced."ISCN 2005" also contains a detachable fold-out of the normal human karyotype, consisting of photographs of G-banded and R-banded chromosomes at the commonly examined 550-band resolution stage and their diagrammatic representations - a useful aid for human cytogeneticists, technicians, and students. ... Read more

Customer Reviews (1)

Excellent¡¡¡
The book was received earlier than expected. It's wonderful. Useful in my work, I recommend it. ... Read more

Product Description
Data Analysis and Visualization in Genomics and Proteomics is the first book addressing integrative data analysis and visualization in this field. It addresses important techniques for the interpretation of data originating from multiple sources, encoded in different formats or protocols, and processed by multiple systems.

• One of the first systematic overviews of the problem of biological data integration using computational approaches
• This book provides scientists and students with the basis for the development and application of integrative computational methods to analyse biological data on a systemic scale
• Places emphasis on the processing of multiple data and knowledge resources, and the combination of different models and systems
  

Customer Reviews (1)

Nice overview, but lacks detail
This book provides a nice overview of some important genomics and proteomics databases and analysis techniques, but doesn't go into much detail anywhere, especially not on data visualization. ... Read more

Product Description
Presents the principles of human gene evolution in a concise and easy to understand fashion. Uses examples of how evolutionary processes have molded present day genes, drawn from the evolution of humans and other primates, as well as from more primitive organisms. With increasing attention in this expanding area, this review forms a timely publication of our current knowledge of this important field.

Key Features
* Structure and function in the human genome
* The evolution of gene structure
* Mutational mechanisms in evolution ... Read more

Customer Reviews (1)

an amazing compendium
This book is an amazing compendium of interesting facts about the evolution of our genome.It is comprehensive without being boring.I am writing this review in 2003, rather late for a 1999 book, because it is so good I felt it shouldn't be listed on Amazon without at least one review from a reader.I hope that the author will update it with a second edition incorporating new data from the sequencing of the human genome, which was "completed" after this book was published. ... Read more

Product Description

Cancer Informatics in Post-Genomic Era provides both the necessary methodology and practical information tools for analyzing data in the field of medical information science. This, of course, requires analytic tools. Those tools are garnered by developing and assessing methods and systems for the acquisition, processing, and interpretation of patient data, aided by scientific discovery. Key challenges in this field include integrating research and clinical care, sharing data, and establishing partnerships within and across sectors of patient diagnosis and treatment.

Product Description
An excellent review of the relationship between structure and function in the human genome, and a detailed description of some of the important methodologies for unravelling the function of genes and genomic structures. ... Read more