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This comprehensive resource guide reflects an analysis of theworld literature, for the period between 1983 and June, 1995. Itprovides a succinct overview of the current status of biologicalmodels that can facilitate advances in the development of drugs andradiopharmaceuticals and allows rational choices of the appropriatemodels for investigations specific to understanding disease processesand the development of treatments for diseases afflicting society andits members. Guidelines for the use of animals in research are necessarilyre-stated in this monograph, as well as brief remarks concerningalternatives. A brief review of philosophical, ethical and moralarguments concerning the use of animals in research and testing isprovided as background on the past and current situation in the use ofanimals. Biological Models in Radiopharmaceutical Development is anindispensable resource for radiopharmaceutical scientists,pharmacists, physicians, veterinarians, post- graduate researchers,members of animal care and ethics committees and other professionalsinvolved in biomedical research, drug and radiopharmaceuticaldevelopment. ... Read more

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Human cancer is now generally accepted as being primarily the result of a multitude of interacting environmental factors. This study offers coverage of the ability of exogenous influences to modify tumourigenesis in the organs most often involved in cancer. The first theoretical section highlights the principles now thought to underlie neoplasia in rodents and how they can be applied to in vivo risk assessment. In the second section, experienced researchers discuss the modification of tumour development in the gastrointestinal tract, liver, pancreas, lung, urinary bladder, breast and skin. Both endogenous and exogenous influences and their possible interactions are considered, with emphasis placed on dietary and other factors relevant to the human situation. ... Read more

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Hardbound. New legislation enacted in many countries and regions of the world during the 1980s requires that laboratory animal use be reduced, refined and replaced wherever possible, for ethical and scientific reasons, in line with the Three Rs concept put forward by W.M.S. Russell and R.L. Bnurch in 1958, in The Principles of Humane Experimental Technique. This Congress provided an opportunity for a celebration of the 40th anniversary of the publication of this book, and for a coming together of many of those who are actively pursuing the implementation of the Three Rs in the interests of good science and humane science. Current uses and future prospects for the use of laboratory animal procedures and non-animal methods in the biomedical sciences are considered in five themes: the development of replacement alternative methods; the validation and regulatory acceptance of alternative test methods; reduction alternatives and the testi ... Read more