Geometry.Net - Basic_C: Cancer & Genetics

Cancer.gov - Prevention, Genetics, Causes
Informative site providing detailed information about genetics, causes, risk factors, and prevention of cancer. The information is aimed at both patients and health professionals from the Nat'l. cancer Inst.
http://www.cancer.gov/cancerinfo/prevention-genetics-causes

Extractions: Prevention and/or genetics information is available for the following types of cancer: Breast Cancer: Prevention, Genetics, Causes Cervical Cancer: Prevention, Genetics, Causes Colon and Rectal Cancer: Prevention, Genetics, Causes Endometrial Cancer: Prevention, Genetics, Causes ... Stomach Cancer: Prevention, Genetics, Causes General Information
CMGS-Cancer Molecular Genetics/Part 2 Study Day 19.02.01
MRCPath Part 2 study day 2001. Recent developments / Future provision of cancermolecular genetics. Methods for cancer genetics and Prognosis Prediction.
http://www.ich.ucl.ac.uk/cmgs/part2/cancerde.htm

Extractions: MRCPath Part 2 study day 2001 Recent developments / Future provision of cancer molecular genetics Imprinting and Cancer Tumour-suppressor genes are accepted to be commonly inactivated by mutations, however, for some TS genes an epigenetic pathway may be more common. In a cancer cell there is a clear distortion in expression profiles, much of which can be explained by a dramatic change in methylation patterns. Dysregulation of methylating enzymes, global methylation (possibly causing global genomic fragility) and, local and discrete hypermethylation are all seen. Hypermethylation of TS genes is associated with loss of expression, absence of a coding mutation, and restoration of transcription by demethylating agents. It has been recorded for many tumour types: MSI is a feature of (familial) HNPCC due to MMR gene mutations. However, MMR mutations are found in only 10%of MSI positive (MSI+) sporadic cases. The MLH1 promoter is hypermethylated in the remaining 90% MSI+ tumours. Of MSI- tumours, 95% exhibit a normal pattern of methylation of MLH1. Hypermethylaion of MLH1 has been shown to be an early event in tumourigenesis. E-cadherin Promoter hypermethylaion demonstrated in sporadic gastric, breast, prostate and colorectal cancers.
Designer Genes, Inc.
Develop and sell novel geneticsbased detection technologies for diagnosing and monitoring cancer and other diseases. Products include both diagnostic reagent kits and medical diagnostic devices.
http://designergenesinc.com/
NEJM -- Sign In
Book Review from The New England Journal of Medicine ProstateCancer Biology, genetics, and the New Therapeutics.
http://content.nejm.org/cgi/content/full/346/21/1677-a

Extractions: Registered Users User Name Password Remember my user name and password. Forgotten the password? If you do not use cookies sign in here If you have purchased access to an article or the Journal website, you may regain access here First-Time Users If you are a Journal subscriber using the Journal On-line for the first time, you must register and choose a password. If you are not a Journal subscriber subscribe here If you would like full access to the Journal Web site for 24 hours for $29, click here
ScienceDirect - Cancer Genetics And Cytogenetics - List Of Issues
Flip book and CDROM on genetics and breast cancer. Similar pages HMRL ProjectsBreast cancer and genetics Website Project Name cancer and genetics. StatusCompleted.
http://www.sciencedirect.com/science/journal/01654608
Cancer Genetics Counseling Handbook
from the US Army, the HMRL and the University of Michigan Breast and Ovarian cancerRisk Evaluation Program developed a cancer and genetics counseling handbook
http://healthmedia.umich.edu/HMRL2000/HTML/Projects/CancerandGeneticsCounselin.h
Genetics Northwest - Kristen Beck - Genetic Counselor
Offers prenatal and cancer genetic counseling, and genetic testing including paternity testing and Native American ancestry testing. A genetics library is also available for interlibrary loan and document delivery.
http://www.geneticsnw.org/

Extractions: Genetic Counselor What are genetic counselors? Genetic counselors are health professionals with specialized graduate degrees and experience in the areas of medical genetics and counseling. Most enter the field from a variety of disciplines, including biology, genetics, nursing, psychology, public health and social work. Genetic counselors provide information and support to families who have members with birth defects or genetic disorders and to families who may be at risk for a variety of inherited conditions. They identify families at risk, investigate the problem present in the family, interpret information about the disorder, analyze inheritance patterns and risks of recurrence, and review available options with the family. Genetic counselors also provide supportive counseling to families, serve as patient advocates, and refer individuals and families to community or state support services. They serve as educators and resource people for other healthcare professionals and for the general public. Some counselors also work in administrative capacities. Many engage in research activities related to the field of medical genetics and genetic counseling. Definition adopted by the National Society of Genetic Counselors , Inc. 1983
Sidney Kimmel Cancer Center: News Story In Cancer & Genetics, Nov. 1994
News Story in cancer genetics, Nov. 1994 November, 1994 Antisense TargetingTGFbeta Seen as Way to Thwart cancer's Immuno-suppression
http://www.skcc.org/news/stories/110194.html

Extractions: By targeting transforming growth factor beta (TGF-beta)with an antisense oligonucleotide, scientists think they have found a way to overcome one of the more perplexing problems of cancer immunotherapy-a mechanism by which tumors suppress the immune system. A study conducted by Dr. Habib Fakhrai at the San Diego Regional Cancer Center(SKRCC) [now Sidney Kimmel Cancer Center] showed that while transfer of genetically modified IL-2 tumor genes was successful in stimulating the immune response against cancer, it also triggered a countermeasure by the threatened malignant cells. He presented the results of his study at the third annual International Conference on Gene Therapy of Cancer, held in San Diego and sponsored by the SDRCC and Sharp HealthCare. It turns out that while the immune system is getting a boost, through the introduction of cytokines such as IL-2, immuno-suppressant factors, produced by the tumors, also act to suppress the awakened immune system. But Fakhrai's study showed a way around even those defenses.
Cell -- Archive Of Issues By Date
Published biweekly, it includes original research articles of exceptional significance in areas including molecular biology, biochemistry, cancer research, cell biology, developmental biology, genetics, immunology, microbiology, neurobiology, plant biology, structural biology and virology.
http://www.cell.com/contents-by-date.0.shtml
Sidney Kimmel Cancer Center: News Story In Cancer & Genetics Report, April, 1996
News Story in cancer genetics Report, April, 1996 April, 1996 ScientistsRemove Tumor's Mask by Switching Off TGFBeta With AntiSense
http://www.skcc.org/news/stories/040196.html

Extractions: Researchers at the Sidney Kimmel Cancer Center (SKCC) and the University of California, L.A. have confirmed earlier rat studies in which aggressive brain cancers disappeared after scientists switched off transforming growth factor-beta (TGF-Beta), an immunosuppressant that normally "masks" the cancer from the immune system. According to Dr. Habib Fakhrai of U.C.L.A., brain tumors "disappeared" in all rats and did not return even when researchers exposed the rats to additional tumor cells. "Although TGF-Beta is not my discovery.", Dr. Habib Fakhrai said, "my original contribution is asking the question, 'what happens if you knock-off TGF-Beta'?" The scientists used an antisense targeting technique, co-invented by Fakhrai, Robert E. Sobol, and Oliver Dorigo at SKCC, that was able to thwart the tumor's ability to evade immune system detection. Early results of animal trials were first presented in November '94 at a gene therapy conference in San Diego. Since then, the scientists have performed histological studies and re-challenged with an additional 100,00 glioblastoma tumor cellsthe treated rats whose tumors had disappeared. All the animals survived.
Hospital Practice: Genetics Series
Features articles on applied molecular genetics on topics such as cancer, obesity, and nervous disorders. Offers a journal search engine.
http://www.hosppract.com/genetics.htm
Molecular Biology Of Prostate Cancer - Cancer GeneWeb - Guide To Internet Resour
AND chromosome 8 (PubMed) Limit search to Last Year Limit search to Last 2Years Limit search to Reviews Prostate cancer genetics Prostate cancer
http://www.cancerindex.org/geneweb/X0904.htm
Cancer GeneticsWeb - Home Page
cancer geneticsWeb www.cancergenetics.org,
http://www.cancerindex.org/geneweb/

Extractions: www.cancer genetics.org This site includes pages for 605 cancer related genes and entries for 176 chromosome abnormalities. Search: Welcome If you are a first time visitor please read the introduction The site is primarily intended for health professionals and researchers. The aim of the site is to provide comprehensive links to reliable information about genes, their associated proteins, and genetic mutations associated with cancer and related disorders. Each gene page includes links to major genetic databases and where possible links to other related web sites, abstracts references, external searches, and summary information. The site is integrated with Guide to Internet Resources for Cancer to provide links to related clinical and research information sources. Please note: the site includes putative oncogenes / tumour supressor genes and proto-oncogenes implicated in cancer but for which the association with cancer is not necessarily proven. Links to other databases and research abstracts and pre-configured searches of PubMed are included to provide a gateway to available evidence and the latest research relating to specific genes and their role in cancer.
LU:research - Lund University Institutional Archive
Title Hereditary Nonpolyposis Colorectal cancer Molecular Geneticsand Biology of Associated Tumors. Authors Planck, Maria. Year 2002.
http://eprints.lub.lu.se/archive/00009587/

Extractions: About Planck, Maria UNSPECIFIED Thesis or Dissertation Hereditary Nonpolyposis Colorectal Cancer - Molecular Genetics and Biology of Associated Tumors Hereditary nonpolyposis colorectal cancer, MLH1, MSH2, MSH6, Microsatellite instability, Coding repeats, Mismatch repair protein expression, Colon cancer, Rectal cancer, Endometrial cancer, Small bowel cancer This thesis focuses on one of the most common types of hereditary cancer, hereditary nonpolyposis colorectal cancer (HNPCC). This syndrome is characterized by an autosomal dominant inheritance, an increased risk for several types of cancer (especially cancer of the colorectum, small bowel, endometrium, ovary and urinary tract), early age at diagnosis, and frequent development of multiple primary malignancies. HNPCC is caused by a germline mutation in one of several DNA mismatch-repair (MMR) genes. In paper I, we screened 16 families with suspected HNPCC for germline MMR gene mutations and found a diverse spectrum of mutations, involving the MMR genes MLH1, MSH2 and MSH6 . A defective MMR is associated with microsatellite instability (MSI) in the tumor tissue and with somatic mutations in repeated sequences in several cancer-associated genes. In paper II, we studied the occurrence of such alterations in 24 tumors from 14 individuals in an HNPCC family with a germline MSH2 mutation and found an extensive intra- and inter-individual variation. Paper III demonstrates intratumoral heterogeneity of repeat-mutations in 10 macroscopically different areas of a colon carcinoma in a patient with a germline MLH1 mutation. The variation in the somatic mutations in repeat-containing genes suggests that these alterations are important for tumor progression rather than initiation and that the accumulation of mutations, rather than the specific alterations, drives HNPCC tumorigenesis.
Carolina Georgia Cancer Genetics Network Center
What is the cancer genetics Network? The cancer 4cancer. Thank youfor your interest in the cancer genetics Network! Back To Top.
http://cancer.med.unc.edu/cancergenetics/

Extractions: More information about cancer The Cancer Genetics Network (CGN) is a national effort funded by the National Cancer Institute. The purpose of the Cancer Genetics Network is to help scientists and health care providers understand the causes of cancer, and to help them detect, prevent and treat cancer. The Network includes eight centers working together to create a registry, or list, of individuals at increased risk for cancer who are willing to learn about and possibly participate in future research projects developed through the Cancer Genetics Network. The Cancer Genetics Network will collect basic medical and family information on each participant. This information will be updated every year and may be useful in answering some basic research questions about cancer and genetics.
DCEG - Division Of Cancer Epidemiology And Genetics
The Division of cancer Epidemiology and genetics (DCEG) is the primary focuswithin the National cancer Institute for populationbased research on
http://dceg.cancer.gov/

Extractions: NCI's News Center The Division of Cancer Epidemiology and Genetics (DCEG) is the primary focus within the National Cancer Institute for population-based research on environmental and genetic determinants of cancer. Intramural and collaborative interdisciplinary studies are conducted on the distribution, causes, and natural history of cancer, and the means for its prevention. Research areas of special interest include genetic predisposition, lifestyle factors, environmental contaminants, occupational exposures, medications, radiation and infectious agents, as well as statistics and methods development. Overview and operating philosophy Biography of Dr. Joseph F. Fraumeni, Jr., Director
Breast Cancer And Genetics
Cristina Artale Breast cancer. I presented my presentation on Monday,January 10, 2000. I tried to touch every section of breast cancer.
http://www.angelfire.com/ms/perring/artale.html

Extractions: Cristina Artale Breast Cancer I presented my presentation on Monday, January 10, 2000. I felt that the presentation went well considering the amount of time that I had to prepare. I chose to go first because I wanted to get it out of the way. I did not realize, however, that there was so much information about this topic to cover. I tried to touch every section of breast cancer. I tried to go into as much detail as possible and keep the presentation 10-15 minutes. Most of the feedback that I received was that I read off of the overhead. I had many facts about breast cancer that I could not have memorized. I did not have that long to prepare for this presentation. It would have been difficult to memorize all of this information. I tried to look up and make eye contact every now and then, but I do not think I was too successful. Another criticism I received was that I used "um" and "like" a lot. I have a very bad habit of that. When I get nervous I always use these words. My presentation was about breast cancer. Breast cancer is the most common malignancy among women in the United States. Rates in the United States are among the highest in the world. The chance that a woman gets breast cancer increases as she gets older. In fact, the majority of cases occur after the age of fifty. Over the years, mortality rates have decreased due to mammograms. Mammograms are very important. They can detect breast cancer early. Many women are now having mammograms done to check for cancer. Although, many women still do not get mammograms. This is a change from a number of years ago. Many women never used to get mammograms. This is why the mortality rate has come down. Many married women and women over the age of 60 have been reported as the group in which women do not have mammograms done. It has been reported that these women feel it is not necessary to get one because of their age, even though the statistics prove them wrong.
Cancer And Genetics (Overview)
Table of ContentsCancer and genetics Answering Your Patients' Questions, writtenby Randi Londer Gould in collaboration with Henry T. Lynch, MD, Robert A
http://www.cancernetwork.com/library/cangenet.htm

Extractions: Cancer and Genetics: Answering Your Patients' Questions , written by Randi Londer Gould in collaboration with Henry T. Lynch, MD, Robert A. Smith, MD, and James F. McCarthy, is a joint venture of PRR, Inc., and the American Cancer Society. Intended as a manual for clinicians and their patients, Cancer and Genetics covers such topics as the physician's role in genetic counseling and testing; the genetics of breast, ovarian, colon, and other cancers; assessing risk in families with a history of cancer; and dealing with discrimination in the workplace and privacy issues. Also included are glossary of terms, a state-by-state directory of genetic counselors, and regional and national resources for further information. Table of Contents Other Books Other Publications
What Causes Cancer
Diet and cancer. genetics and cancer. Types of cancer. List of types of cancer. Mammography.Pink Ribbon Campaig. genetics and cancer. page being updated.
http://www.cancer.ie/information/genetics/

Extractions: Donate Action Breast Cancer Cancer Helpline Volunteers ... Homepage Patient Care Cancer Helpline Dealing with a diagnosis Home Care Night Nursing ... Chat Cancer Information What is cancer What causes cancer How cancer is diagnosed How cancer is treated ... Genetics and cancer Types of cancer List of types of cancer Glossary of terms Cancer Research Research Progress against cancer Types of research Clinical Trials Nursing Research Projects Funded Application Forms Education Professional Education Schools Education Workplace Education Public Lectures ... Daffodil Bursary Smoking Passive Smoking Benefits of Quitting Tips for Quitting Smoking Quitline ... ASH Fundraising Become a volunteer Daffodil Day Terry Fox Run's Easter Walk ... Special Events Society Information Board of Directors Site Bibliography Contact us Recruitment Action Breast
Cancer Genetics Network
cancer genetics Network The cancer genetics Network (CGN) is a national networkof centers specializing in the study of inherited predisposition to cancer.
http://epi.grants.cancer.gov/CGN/

Extractions: click image to enlarge Shortcuts Enrollment Open for Study To Find Ovarian Cancer Early Cancer Information Service: telephone education and information service from NCI Cancer Family Registries Other NCI Research Resources ... BRCA Research Testing Agreement Cancer Genetics Network A resource supporting the research community at large Opportunities for the public to enroll still open The Cancer Genetics Network (CGN) is a national network of centers specializing in the study of inherited predisposition to cancer. The resource is available to the research community at large to support studies on the genetic basis of human cancer susceptibility, the integration of this information into medical practice, and on the psychosocial, ethical, legal, and public health issues associated with human genetics. The CGN's interests include: gene discovery gene characterization gene-environment interaction translational research behavioral research.

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